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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Principles of method if other than guideline:
The particle size distribution of calcium carbonate (amorphous form) has been determined.
GLP compliance:
no
Type of method:
sedimentation (gravitational settling)
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium carbonate
EC Number:
207-439-9
EC Name:
Calcium carbonate
Cas Number:
471-34-1
Molecular formula:
CH2O3.Ca
IUPAC Name:
calcium carbonate
Test material form:
solid: bulk
Remarks:
amorphous

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D50
Mean:
1.494 µm
Percentile:
other: 95.0%
Mean:
< 2.414 µm
Remarks on result:
other: N/A
Percentile:
other: 84.0%
Mean:
< 1.977 µm
Remarks on result:
other: N/A
Percentile:
other: 50.0%
Mean:
< 1.494 µm
Remarks on result:
other: N/A
Percentile:
other: 16.0%
Mean:
< 1.127 µm
Remarks on result:
other: N/A
Percentile:
other: 5.0%
Mean:
< 0.908 µm
Remarks on result:
other: N/A

Applicant's summary and conclusion

Conclusions:
The particle size distribution data indicates that 95% of calcium carbonate (amorphous form) particles have a diameter of <2.414 µm and therefore can be considered to be potentially inhalable.