Registration Dossier
Registration Dossier
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EC number: 234-018-7 | CAS number: 10493-43-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Objective of study:
- absorption
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of the study was to determine if the test substance undergoes absorption and metabolism after inhalation exposure in rats.
- GLP compliance:
- not specified
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
Doses / concentrationsopen allclose all
- Dose / conc.:
- 100 ppm
- Dose / conc.:
- 500 ppm
- Dose / conc.:
- 2 000 ppm
- Dose / conc.:
- 5 000 ppm
- Control animals:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Tissue-to-air partition coefficients were collectively negative, and the data suggest that very little uptake of test substance occurs into tissues. According to the method used, it is likely that the blood-to-air partition of <0.5 would be observed. Thus only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled. This observation was supported by the preliminary gas uptake data.
Comparison of 2000 ppm exposure and control exposure indicated that the test substance does not undergo significant uptake and metabolism. At 100 ppm, an initial uptake of test substance is apparent in the first 75 minutes, but chamber concentration levels off indicating no further metabolism.
Applicant's summary and conclusion
- Conclusions:
- Only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled.
- Executive summary:
The objective of the study was to determine if the test substance undergoes absorption and metabolism after inhalation exposure in rats. Rats were exposed to concentrations of 0, 100, 500, 2000, or 5000 ppm via inhalation. Tissue-to-air partition coefficients were collectively negative, and the data suggest that very little uptake of test substance occurs into tissues. According to the method used, it is likely that the blood-to-air partition of <0.5 would be observed. Thus only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled. This observation was supported by the preliminary gas uptake data. Comparison of 2000 ppm exposure and control exposure indicated that the test substance does not undergo significant uptake and metabolism. At 100 ppm, an initial uptake of test substance is apparent in the first 75 minutes, but chamber concentration levels off indicating no further metabolism.
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