Registration Dossier
Registration Dossier
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EC number: 283-905-5 | CAS number: 84775-75-7 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Artemisia herba-alba, Compositae.
Endpoint summary
Administrative data
Description of key information
Using the typical composition of Artemisia herba-alba oil (thujone type), ecotoxicity results are as follow:
- Aquatic Invertebrates: 48-h EL50 was 36 mg test material/L (lowest acute E(L)C50 value)
- Aquatic algae: 72-h ErL50 was 64 mg test material/L
Based on these results, the lowest acute E(L)C50 is higher than 1 mg/L.
Therefore, the registered substance would not be classified as acute 1 to aquatic organisms in accordance with the classification of the CLP.
Additional information
The registered substance is a Natural Complex Substance (UVCB) with a well-defined composition for which the relative percentage of each constituent is known.
Therefore, it has been decided that the ecotoxicity of the substance will be derived from knowledge of the constituents.
Acute toxicities to aquatic organisms have been investigated using an in-house calculation method that replaces OECD 201 and 202 studies and guideline for Testing of Chemicals No. 23 (i.e. WAF conditions). The typical composition has been investigated.
Short-term toxicity to fish was not provided in the dataset since the tonnage band (1 -10 tonnes/year) does not require that endpoint.
CLP Classification proposal
It is proposed to compare submission substance dataset to CLP environmental criteria laid down in CLP Regulation (including 2nd Adaptation to Technical Progress, Com Reg No 286/2011).
Acute aquatic hazard: not classified. Reasoning: lowest E(L)C50 higher than 1 mg/L.
Chronic aquatic hazard: category 3. Reasoning: adequate chronic toxicity data are not available, lowest acute E(L)C50 value is between 10 and 100 mg/L, rapidly degradable substance with at least one constituent having a Log Kow > 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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