Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-677-4 | CAS number: 68-11-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of various compounds on the reaction of tris-(2-chloroethyl)amine with ribonucleic acid in vitro and on its toxicity in mice
- Author:
- Szinicz L, Albrecht GJ and Weger N
- Year:
- 1 981
- Bibliographic source:
- Arzneim -Forsch, 31 (11), 1713-1717
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other: no data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mercaptoacetic acid
- EC Number:
- 200-677-4
- EC Name:
- Mercaptoacetic acid
- Cas Number:
- 68-11-1
- Molecular formula:
- C2H4O2S
- IUPAC Name:
- 2-sulfanylacetic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Weight: 20-25g
Diet: standard ad libitum
Water: ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Doses:
- no data
- Statistics:
- LD90, LD50, LD5 calculated according to the Litchfield and Wilcoxon
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 138 mg/kg bw
- 95% CL:
- 133 - 143
- Sex:
- male
- Dose descriptor:
- other: LD5
- Effect level:
- 115 mg/kg bw
- 95% CL:
- 96 - 138
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
