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EC number: 946-638-1 | CAS number: -
- Life Cycle description
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Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 4 to 10 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Council Regulation (EC) No 761/2009 of 23 July 2009
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on 13 and 14 October 2014 / signed on 08 April 2015
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 1 923 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 2 415 Pa
- Conclusions:
- The vapour pressure of the test item was calculated as 1923 Pa at 20 °C and 2415 Pa at 25 °C (interpolation)
- Executive summary:
The vapour pressure of the test item was measured under GLP using the static method as described in EU method A.4 and OECD 104.
Ten determinations of vapour pressure were performed in a temperature range of 16.1 – 47.8 °C and the pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be interpolated.
The vapour pressure of the test item was calculated as 1923 Pa at 20 °C and 2415 Pa at 25 °C. (interpolation)
Reference
Table 4.6/1: Measurement Values
1. Determination |
2. Determination |
||||
Temp. in °C |
Date/Time |
Pressure in hPa* |
Temp. in °C |
Date/Time |
Pressure in hPa* |
20.0 |
04. Jan. 2017 / 11:30 |
18.6 |
40.0 |
05. Jan. 2017 / 15:55 |
41.5 |
27.1 |
04. Jan. 2017 / 14:54 |
25.2 |
34.0 |
06. Jan. 2017 / 09:00 |
35.2 |
34.0 |
04. Jan. 2017 / 16:15 |
32.2 |
27.1 |
06. Jan. 2017 / 14:55 |
30.2 |
40.0 |
05. Jan. 2017 / 07:35 |
50.2 |
20.0 |
09. Jan. 2017 / 11:10 |
18.8 |
47.8 |
05. Jan. 2017 / 09:15 |
65.8 |
16.1 |
10. Jan. 2017 / 09:42 |
16.8 |
The calculation results are presented in the following table:
Table 4.6/2: Calculated values for 1/T and log P
n |
Temperature T |
Pressure P |
Temperature T |
1/T |
log P |
|
°C |
hPa* |
K |
1/K |
log Pa |
1 |
20.0 |
18.6 |
293.15 |
0.00341122 |
3.2695 |
2 |
27.1 |
25.2 |
300.25 |
0.00333056 |
3.4014 |
3 |
34.0 |
32.2 |
307.15 |
0.00325574 |
3.5079 |
4 |
40.0 |
50.2 |
313.15 |
0.00319336 |
3.7007 |
5 |
47.8 |
65.8 |
320.95 |
0.00311575 |
3.8182 |
6 |
40.0 |
41.5 |
313.15 |
0.00319336 |
3.6180 |
7 |
34.0 |
35.2 |
307.15 |
0.00325574 |
3.5465 |
8 |
27.1 |
30.2 |
300.25 |
0.00333056 |
3.4800 |
9 |
20.0 |
18.8 |
293.15 |
0.00341122 |
3.2742 |
10 |
16.1 |
16.8 |
289.25 |
0.00345722 |
3.2253 |
*hPa = mbar
The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:
Table 4.6/3.- Linear Regression Parameters
Parameter |
Value |
Slope |
-1730.155622 |
Intercept |
9.185855917 |
Correlation coefficient r |
-0.984732753 |
Coefficient of determination r2 |
0.969698594 |
Table 4.6/4 .- Calculated Values for vapour pressure
Parameter |
Value |
Unit |
Vapour Pressure (20 °C) |
1923 |
Pa |
Vapour Pressure (25 °C) |
2415 |
Pa |
Discussion
The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.
From the measured values, the vapour pressure of the test item was calculated as 1923 Pa at 20.0 °C and 2415 Pa at 25 °C.
During determination, it took a long time until equilibrium was reached, especially the cooling-down phase. It was supposed because of the physical state of the test item (Paste like or wax) and the test item is a NCS (natural compound substance). However, the values of the heating and cooling down phase showed sufficient correspondence (the coefficient of determination (r2) is greater than 0.95)
Therefore, the result of the study is considered valid.
Description of key information
The vapour pressure of the test item was calculated as 1923Pa at 20°C and 2415Pa at 25 °C (interpolation).
Key value for chemical safety assessment
- Vapour pressure:
- 2 415 Pa
- at the temperature of:
- 25 °C
Additional information
A fully reliable experimental study conducted according to a recognized OECD/EC method and under GLP, is available.
Therefore it is considered as a key study and the result is retained as key data for the purpose of CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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