Concrete of Rosa Damascena (Rosaceae) obtained from fresh flowers by extraction with an apolar solvent

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 4 to 10 January 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Council Regulation (EC) No 761/2009 of 23 July 2009

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on 13 and 14 October 2014 / signed on 08 April 2015

Type of method:

static method

Key result

Temp.:

20 °C

Vapour pressure:

1 923 Pa

Key result

Temp.:

25 °C

Vapour pressure:

2 415 Pa

Table 4.6/1: Measurement Values

1. Determination increasing temperature			2. Determination decreasing temperature
Temp. in °C	Date/Time	Pressure in hPa*	Temp. in °C	Date/Time	Pressure in hPa*
20.0	04. Jan. 2017 / 11:^30	18.6	40.0	05. Jan. 2017 / 15:^55	41.5
27.1	04. Jan. 2017 / 14:^54	25.2	34.0	06. Jan. 2017 / 09:^00	35.2
34.0	04. Jan. 2017 / 16:^15	32.2	27.1	06. Jan. 2017 / 14:^55	30.2
40.0	05. Jan. 2017 / 07:^35	50.2	20.0	09. Jan. 2017 / 11:^10	18.8
47.8	05. Jan. 2017 / 09:^15	65.8	16.1	10. Jan. 2017 / 09:^42	16.8

The calculation results are presented in the following table:

Table 4.6/2: Calculated values for 1/T and log P 

n	Temperature T	Pressure P	Temperature T	1/T	log P
	°C	hPa*	K	1/K	log Pa
1	20.0	18.6	293.15	0.00341122	3.2695
2	27.1	25.2	300.25	0.00333056	3.4014
3	34.0	32.2	307.15	0.00325574	3.5079
4	40.0	50.2	313.15	0.00319336	3.7007
5	47.8	65.8	320.95	0.00311575	3.8182
6	40.0	41.5	313.15	0.00319336	3.6180
7	34.0	35.2	307.15	0.00325574	3.5465
8	27.1	30.2	300.25	0.00333056	3.4800
9	20.0	18.8	293.15	0.00341122	3.2742
10	16.1	16.8	289.25	0.00345722	3.2253

*hPa = mbar

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Table 4.6/3.- Linear Regression Parameters

Parameter	Value
Slope	-1730.155622
Intercept	9.185855917
Correlation coefficient r	-0.984732753
Coefficient of determination r^2	0.969698594

 

Table 4.6/4 .- Calculated Values for vapour pressure

Parameter	Value	Unit
Vapour Pressure (20 °C)	1923	Pa
Vapour Pressure (25 °C)	2415	Pa

Discussion

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 1923 Pa at 20.0 °C and 2415 Pa at 25 °C.

During determination, it took a long time until equilibrium was reached, especially the cooling-down phase. It was supposed because of the physical state of the test item (Paste like or wax) and the test item is a NCS (natural compound substance). However, the values of the heating and cooling down phase showed sufficient correspondence (the coefficient of determination (r²) is greater than 0.95)

Therefore, the result of the study is considered valid.

Conclusions:

The vapour pressure of the test item was calculated as 1923 Pa at 20 °C and 2415 Pa at 25 °C (interpolation)

Executive summary:

The vapour pressure of the test item was measured under GLP using the static method as described in EU method A.4 and OECD 104.

Ten determinations of vapour pressure were performed in a temperature range of 16.1 – 47.8 °C and the pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be interpolated.

The vapour pressure of the test item was calculated as 1923 Pa at 20 °C and 2415 Pa at 25 °C. (interpolation)

Description of key information

The vapour pressure of the test item was calculated as 1923Pa at 20°C and 2415Pa at 25 °C (interpolation).

Key value for chemical safety assessment

Vapour pressure:

2 415 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study conducted according to a recognized OECD/EC method and under GLP, is available.

Therefore it is considered as a key study and the result is retained as key data for the purpose of CSA.