Registration Dossier
Registration Dossier
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EC number: 255-078-0 | CAS number: 40783-05-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- other: BASF method
Test material
- Reference substance name:
- 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
- EC Number:
- 255-078-0
- EC Name:
- 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
- Cas Number:
- 40783-05-9
- Molecular formula:
- C36H16Cl2N4O4
- IUPAC Name:
- 2-(2,5-dichloro-4-{6,11-dioxo-1H,6H,11H-anthra[1,2-d]imidazol-2-yl}phenyl)-1H,6H,11H-anthra[1,2-d]imidazole-6,11-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Inhalation by means of vapour saturated atmosphere at 20 °C for 8 hours. To achieve saturation, air was fed through an approx. 5 cm deep layer of the product.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- saturation concentration
- No. of animals per sex per dose:
- 12 rats in total
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observation, weekly weighing
- Necropsy of survivors performed: yes - Statistics:
- n.a.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: no effect at saturation concentration
- Mortality:
- No mortality
- Clinical signs:
- other: no symptoms
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 8 hours inhalation of a saturated atmosphere did not lead to any deaths in rats (0/12).
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