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Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guidelineopen allclose all
Guideline:
other: OECD Guideline for testing of chemicals - draft proposal - February 2000: Transformation dissolution of metals and metal compounds in aqueous media.
Guideline:
other: ISO 6341
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Slags, ferrochromium-manufg.
EC Number:
273-727-6
EC Name:
Slags, ferrochromium-manufg.
Cas Number:
69012-27-7
IUPAC Name:
silicon(4+) dialuminium(3+) dichromium(3+) pentamagnesium(2+) undecaoxidandiide silicate
Details on test material:
HCFeCr slag (CAS 69012-27-7), black, solid, insoluble, odourless. Slag is a mixture of different slags of different fabricants.

Composition in %
Cr2O3 7,1 %
FeO 3,3 %
SiO2 29,2 %
Al2O3 24,7 %
MgO 30,2 %
C 0,7 %
CaO 2,2 %
TiO2 0,5 %
Ni 0,05 %
C 0,7 %
S 0,2 %
Co 0,005 %
Mn 0,2 %
Cu 0,002 %
Zn 0,1 %
As.Cd < 0,0002 %
Pb < 0,001 %

Expiration date: not applicable; the product is stable.
Radiolabelling:
no

Test animals

Species:
other: in vitro

Administration / exposure

Route of administration:
other: in vitro
Details on study design:
Solubility teat

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Material is practically insoluble
Details on distribution in tissues:
Material is practically insoluble
Details on excretion:
Material is practically insoluble

Any other information on results incl. tables

The mean (+/- sd) dissolved metal concentrations after 24 hours mg/L

 Cr < 0.006 (detection limit)
Cr6+  < 0.035 (detection limit)
 Fe < 0.050 (detection limit)
 Ni  < 0.005 (detection limit)
 Cd  < 0.0012 (detection limit)
 As  < 0.005 (detection limit)
 Pb  < 0.006 (detection limit)
 Zn  < 0.006 (detection limit)
 Al filtrated  < 0.015 (detection limit)
 Al centrifuged  < 0.015 (detection limit)
 Cu < 0.0025 (detection limit)
 SiO2  < 0.1 (detection limit)
 Co  0.0007
 Mn  < 0.001 (detection limit)

      

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: The material is practically insoluble in water
Material is practically insoluble in water
Executive summary:

Material is practically insoluble in water. The levels of metallic elements (Fe, Cr, Cr(VI),Pb, Mn,Pb,Ni, Cd, Al) as well as As and SiO2 are below the detection limit in transmission dissolution test. Co could be detected but its concentration was close to the detection limit.