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EC number: 204-467-3 | CAS number: 121-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - December, 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Pre-OECD test guideline study and pre-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 3-phenyloxirane-2-carboxylate
- EC Number:
- 204-467-3
- EC Name:
- Ethyl 3-phenyloxirane-2-carboxylate
- Cas Number:
- 121-39-1
- Molecular formula:
- C11H12O3
- IUPAC Name:
- ethyl 3-phenyloxirane-2-carboxylate
- Test material form:
- liquid
1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Three males and two females of the Sherman-Wistar strain.
- Fasting period before study: 24 hours
- Diet: Free access to food
- Water: Free access to water
- Acclimation period: one week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 3.16 mL/kg bw
Doses were administered directly into the stomach by means of a stomach tube. The substance was applied as a 4% solution, the toxicity was converted to 100% substance.
- Doses:
- 1.26, 1.6, 2.0, 2.5 and 3.16 mL/kg bw
- No. of animals per sex per dose:
- Three males and two females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Daily
- Necropsy of survivors performed: No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks:
- the LD50 is converted to the pure substance
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Confidence limits 2000 - 2600 mg/kg.
- Mortality:
- 1/5 animals died at 2.0 mL/kg bw, 4/5 animals died at 2.5 mL/kg bw and all 5 animals died at 3.16 mL/kg bw.
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to EU CLP Regulation (EC) No. 1272/2008 and its amendments
- Conclusions:
- The LD50 is 2300 mg/kg bw and based on this result, the substance is not acute harmful. According to GHS the substance needs to be classified for acute oral toxicity category 5 and labelled with H303: May be harmful if swallowed.
- Executive summary:
In an acute oral toxicity study performed equivalent to OECD 401 guideline, five groups of rats (three males and two females) were orally exposed to a 4% solution of the substance. When converted to 100% substance the doses were 2 – 3.16 ml/kg bw. The rats were observed for signs of toxicity for a period of 14 days. 1/5 animals died at 2.0 mL/kg bw, 4/5 animals died at 2.5 mL/kg bw and all 5 animals died at 3.16 mL/kg bw, resulting in an LD50 of 2.3 mL/kg bw. This will value will be conservatively converted into 2300 mg/kg bw (In view of the relative density of the substance: 1.125, the LD50 is actually 2588 mg/kg bw). Based on this result, the substance is not acute harmful.
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