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EC number: 278-130-4 | CAS number: 75214-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February from 02nd to 06th, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- reference to other study
- Remarks:
- validated analytical method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted July 27, 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 229 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 3.13
- Details on results:
- The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.
PRELIMINARY TEST
The water solubility of the test item was estimated to be ~130 g/l in a preliminary test and therefore the shake-flask method was used in the main test. - Conclusions:
- Water solubility: 229 ± 15.4 g/l at 20 ± 1 °C and pH ca 3.13
- Executive summary:
The water solubility of the test substance was determined by flask method, in accordance with the method and procedures outlined into the OECD guideline 105. The substance concentrations were determined by a previously validated analytical method. The substance was dissolved in water at a temperature somewhat above the test temperature; when saturation was achieved, the mixture was cooled and kept at the test temperature, stirring as long as necessary to reach equilibrium. Subsequently, the mass concentration of the substance in the aqueous solution was determined by HPLC-UV method.
The water solubility of the substance was determined to be 229 ± 15.4 g/l (95 % confidence interval) at 20 ± 1 °C and pH ca 3.13. The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.
Conclusion
Water solubility: 229 ± 15.4 g/l at 20 ± 1 °C and pH ca 3.13
Reference
Results of the determination of test item concentrations
Sampling time | Measured concentration of test item (g/l ) | Measured pH | ||
Test vessels | Mean with the 95% confidence intervals | |||
After 24h | 223 | 225 ± 14.6 | 3.14 | |
232 | 3.12 | |||
222 | 3.13 | |||
After 48h | 232 | 225 ± 13.8 | 3.13 | |
222 | 3.11 | |||
222 | 3.11 | |||
After 72h | 234 | 236 ± 3.7 | 3.12 | |
237 | 3.12 | |||
237 | 3.12 | |||
Solubility of the test item (g/l) | 229 ± 15.4 | - | ||
RSD% | 3 | - | ||
pH of ultra-pure water | - | 6.41 |
Description of key information
Water solubility: 229 ± 15.4 g/l at 20 ± 1 °C and pH ca 3.13
Key value for chemical safety assessment
- Water solubility:
- 100 g/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - flask method
The value for the chemical safety assessment was set to the maximum accepted value of 100 g/l.
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