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EC number: 619-573-9 | CAS number: 855425-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 04.08.2008 to 11.08.2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test was performed in accordance with OECD Guideline 471 for the Testing of Chemicals (Bacterial Reverse Mutation Test. Adopted 21st July 1997) and the test Method BI 3/B14 of Commission Directive 2000/32/EC. The study was performed according to the GLPs.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- CAT-Nitrile
- IUPAC Name:
- CAT-Nitrile
Constituent 1
Method
- Target gene:
- Characteristics of the five strains are described in the following table:
TA98 His D 3052 uvrB pKM101 rfa Frameshift
TA I O0 His G 46 uv rB pKM 1 O1 rfa Base-pair substitution
TA 102 His G 428 pKM 1 O1 - Base- pa¡ r substitut ion
TA 1535 His G 46 UVrB - rfa Base-pair substitution
TA1537 His C 3076 WrB - rfa Frameshift
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 5-1.67-0.5-0.167 and 0.05 mg/plate
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The controls of the test were in concordance with the expected results: - Sterility test showed no contamination during the study. - No cytotoxic effect was observed. - All positive controls performed showed valid ratios (R) above 2.5. - Positive and negative controls showed absolute numbers of revertant colonies comparable to historical data. - No concentration of the test item showed a biological significant increase (R equal or greather than 2.5) of the number of revertant either with or without S9 metabolic activation. - No dose response was observed in none of the tested bacterial strains.
Applicant's summary and conclusion
- Conclusions:
- The following conclusions can be inferred from the obtained results:
- No test substance showed ratios (R) above 2.5 as compared to the negative control, either with or without S9 metabolic activation.
- No dose response was observed in none of the tested bacterial strains.
Based on the results obtained in this study, the test item CAT Nitril was found to be NON MUTAGENIC and NON-PROMUT AGENIC under the test conditions. - Executive summary:
The present Bacterial Reverse Mutation Test (Ames test) was performed in order to evaluate the mutagenic potential of the test item. The test was performed in accordance with OECD Guideline 471 for the Testing of Chemicals (Bacterial Reverse Mutation Test. Adopted 21 st July 1997) and the test Method B13/B14 of Commission Directive 2000/32/EC. Doses ranging from 5 microL to 0.05 microL per plate were tested, where the maximum concentration used was 5mg/plate. No cytotoxicity was observed at any dose. Suspensions of amino-acid reqUiring strains of Salmonella typhimurium (TA98, TA100, TA102, TA1535, TA1537) were exposed by the direct plate incorporation method to five doses of the test item in the presence and in the absence of an exogenous metabolic activation system. Both tests were repeated with the pre-incubation method. The bacteria were allowed to grow for approximately 72h. Only revertant bacteria due to point or frameshift-mutations at specific locus are able to grow, forming colonies. These colonies were counted and compared to the number of spontaneous revertant colonies on solvent control plates (negative control). Similarly, specific standard mutagens were tested and used as positive controls. Based on the results obtained in this study, the test item CAT Nitril was found to be NON MUTAGENIC and NON-PROMUTAGENIC under the test conditions.
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