Registration Dossier
Registration Dossier
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EC number: 271-896-0 | CAS number: 68611-47-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- EC Number:
- 271-896-0
- EC Name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- Cas Number:
- 68611-47-2
- Molecular formula:
- Zn2SiO4:Mn
- IUPAC Name:
- Silicic Acid (H4SiO4), Zinc Salt (1: 2), Manganese-Doped
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Vehicle:
- water
- Control samples:
- yes, concurrent negative control
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- Amount(s) applied :
20 mg solid test substance
VEHICLE
- 20 μl sterile ddH2O
NEGATIVE CONTROL
- 40 μl sterile ddH2O
POSITIVE CONTROL
- 40 μ KOH, 8N (11.3 g KOH in 25 ml of sterile ddH2O) - Duration of treatment / exposure:
- 3 min and 1 hour
- Number of replicates:
- 2
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 min
- Value:
- 104.12
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: non corrosive
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 60 min
- Value:
- 110.43
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: non corrosive
Applicant's summary and conclusion
- Interpretation of results:
- other: non corrosive
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