N-(2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental start date: 17th October 2012. Experimental end date: 07th January 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Test material

Test material information

Constituent 1

Reference substance name:

N4-Benzoylcytosine

EC Number:

628-907-2

Cas Number:

26661-13-2

Molecular formula:

C11H9N3O2

IUPAC Name:

N4-Benzoylcytosine

Specific details on test material used for the study:

Identification: N-Benzoyl Cytosine
Description: Off white powder
Batch: NBC-5-11001
Purity: Not less than 95.0%
Expiry / Retest Date: Not supplied
Storage Conditions: Room temperature, over silica gel, in the dark

Results and discussion

Vapour pressure

Test no.:

#9

Temp.:

25 °C

Vapour pressure:

0 Pa

Any other information on results incl. tables

Discussion

The test item did not change in appearance under the conditions used in the determination.

The preliminary run showed that the vapor pressure of the test item was expected to be very low, and within the range for whihch determination by the vapor pressure balance method was most appropriate.

A sequence of 9 runs was completed and 5 runs have been shown to give an overview of the data obtained.

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropiate to imposes a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 °C.

Run 9 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 210 °C (483.15 K) was chosen because this is the data point which gives the highest estimated vapor pressure at any given temperature when a slope of -1500 K is imposed upon it.

The value of -1500 K is an in-house value and is the shallowest slop eobserved whilst determining the vapor pressure on a wide range of samples using the vapor pressure balance method. Extrapolation to 25 °C gave a vapor pressure of 3.618 x 10^-5 Pa which has been taken as a maximum for this test item.

Applicant's summary and conclusion

Conclusions:

The vapor pressure of the test item has been determined to be less than 3.6 x10-5 Pa at 25 °C

Executive summary:

The vapor pressure of N-benozyl Cytosine has been determined to be less than 3.6 x10^-5 Pa at 25 °C, using the vapor pressure balance method, designed to be compatable with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30th May 2008 and Method 104 of the OECD Guidelines for testing of chemicals, 23 March 2006