Registration Dossier

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic/sediment

This endpoint is fulfilled for Heptadecane using quantitative structure property relationships for representative hydrocarbon structures. The BCFBAF 3.01 model is a well characterised and generally accepted bioaccumulation prediction model, used by the USEPA, the OECD and recommended by ECHA. The SMILES input data for the BCFBAF 3.01 model is obtained from the PETRORISK Product Library (see OECD QSAR Toolbox report in 'Attached full study report' and PETRORISK report attached in IUCLID section 13).

The calculated BCF of Heptadecane ranges from 47.79 - 3974.81 L/kg.

The BCFWIN v2.16 model within EPISuite 3.12 has been used to estimate the bioaccumulation potential of a representative substance. This data is used as a weight of evidence alongside the data reported above.

The calculated BCF of icosane is 22 L/kg cacluatedusing the BCFWIN v2.16 model within EPISuite 3.12. This value indicates that icosane is not considered a bioaccumulative substance.

Bioaccumulation: terrestrial

This endpoint has been calculated for representative hydrocarbon structures including the substances in C14-20 Aliphatics (≤2% aromatic) using the BCFWIN v2.16 model within EPISuite 3.12 as input to the hydrocarbon block method incorporated into the PETRORISK model. The predicted BCFs for hydrocarbons are generally overly conservative since biotransformation is not quantitatively taken into account. Therefore, indirect exposure and resulting risk estimates predicted by PETRORISK are likely to be overestimated. For the purposes of PBT assessment, measured bioaccumulation data for representative hydrocarbon constituents including the substance have been used as detailed in PETRORISK spreadsheet attached to IUCLID section 13.

Additional information

This endpoint has been calculated for representative hydrocarbon structures including the substances in C14-20 Aliphatics (≤2% aromatic) using the BCFWIN v2.16 model within EPISuite 3.12 as input to the hydrocarbon block method incorporated into the PETRORISK model. The predicted BCFs for hydrocarbons are generally overly conservative since biotransformation is not quantitatively taken into account. Therefore, indirect exposure and resulting risk estimates predicted by PETRORISK are likely to be overestimated. For the purposes of PBT assessment, measured bioaccumulation data for representative hydrocarbon constituents including the substance have been used as detailed in PETRORISK spreadsheet attached to IUCLID section 13.

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