Registration Dossier
Registration Dossier
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EC number: 228-630-3 | CAS number: 6310-09-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- In vivo study carried out before the ECHA requirement of in vitro studies for skin irritation!
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- EC Number:
- 228-630-3
- EC Name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- Cas Number:
- 6310-09-4
- Molecular formula:
- C6H5ClOS
- IUPAC Name:
- 1-(5-chlorothiophen-2-yl)ethan-1-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- female
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 h / rabbit
- Observation period:
- 1 hour and 24, 48, 72 hours
- Number of animals:
- 3 female rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not irritating for the skin.
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