Hexyl methacrylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006-10-23 - 2006-11-10

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study OECD 105, non-GLP. Study performed and documented equivalent to GLP standards. Study according to relevant guideline.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

Adopted by the Council on 27th July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Directive 92/69/EC (1992)

Deviations:

no

Principles of method if other than guideline:

The water solubility of a substance is specified by the saturation mass concentration of the substance in water at a given temperature. The water solubility is expressed in mass of solute per volume of solution. The flask method is performed at water solubilities above 10-2 g/L.
In the flask method the substance is dissolved in water at a temperature somewhat above the test temperature. When saturation is achieved, the mixture is cooled an kept at the test temperature until equilibrium is reached. Subsequently, the mass concentration of the substance in the aqueous solution, which must not contain any undissolved particles, is determined by a suitible analytical method.

GLP compliance:

no

Other quality assurance:

other: Tests were carried out according to the requirements of EN ISO 9001

Type of method:

flask method

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Refridgerator 5°C

Key result

Water solubility:

29.9 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 6.1

Remarks on result:

other: an exact pH-value has not been documented

Remarks:

Guideline study OECD 105; relative standard deviation: 2.7 %

Results:

Sample No.	Amount of test item	Added volume of water	Shaking time at 30°C	Analysed concentration of the test item
	(mg)	(mL)	(h)	(mg/L)
1	218.4	40	24	31.3
2	220.4	40	24	30.0
3	241.3	40	48	28.8
4	215.8	40	48	29.7
5	245.3	40	72	30.1
6	228.6	40	72	29.5

	Duplicate set of samples 24 h at 30°C (mg/L)	Duplicate set of samples 48 h at 30°C (mg/L)	Duplicate set of samples 72 h at 30°C (mg/L)	Mean value
Water solubility	30.7	29.2	29.8	29.9

Conclusions:

In a valid guideline study (OECD 105, non-GLP) using the flask method the solubility of n-Hexyl methacrylate in water was determined to be 29.9 mg/L at 20 °C.

Executive summary:

In a valid guideline study (OECD 105, non-GLP) using the flask method the solubility of n-Hexyl methacrylate in water was determined to be 29.9 mg/L at 20 °C.

Analyses were performed by HPLC-UV using external standards.

The relative standard deviation (repeatability) of the concentrations in all six samples was smaller than 15 % and the three duplicate sets of samples showed no tendency of increasing concentration values. Thus the test was satisfactory.

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Description of key information

Determined in a valid experimental study, the solubility of n-hexyl metharcrylate is 29.9 mg/L at 20 °C (OECD GL 105, non-GLP). This is supported by literature.

Key value for chemical safety assessment

Water solubility:

29.9 mg/L

at the temperature of:

20 °C

Additional information

Determined in a valid experimental study, the solubility of n-hexyl metharcrylate is 29.9 mg/L at 20 °C (OECD GL 105, non-GLP). This is supported by literature.