Cloxiquine

Guidance on Safe Use

First-aid measures

If exposure has occurred, do not wait for symptoms to develop, but immediately start the procedures described below.

Ingestion

Call a doctor or get medical attention immediately. Make the exposed person rinse mouth and then drink 1 or 2 glasses of water or milk. Induce vomiting only if:

1. A significant amount (more than a mouthful) has been ingested

2. Patient is fully conscious

3. Medical aid is not readily available

4. Time since ingestion is less than one hour.

Let the patient induce vomiting by touching the back of the throat with a finger. If vomiting occurs, take care that vomit does not enter airways. Let the exposed person rinse mouth and drink fluids again.

Inhalation

If experiencing any discomfort, immediately remove from exposure. Light cases: Keep person under surveillance. Get medical attention immediately if symptoms develop. Serious cases: Get medical attention immediately or call for an ambulance.

If breathing has stopped, immediately start artificial respiration and maintain until a physician takes charge of the exposed person.

Skin contact

Immediately remove contaminated clothing and footwear. Flush with water, followed by washing with water and soap.

Eye contact

Immediately rinse eyes with much water or eyewash solution, occasionally opening eyelids, until no evidence of chemical remains. Remove contact lenses after a few minutes and rinse again.

Fire-fighting measures

Extinguishing media

Dry chemical or carbon dioxide for small fires, water spray or foam for large fires. Avoid heavy hose streams.

Special hazards arising from the substance or mixture:

The essential breakdown products are hydrochloric acid, monochloroacetic acid, phosgene

Advice for firefighters

Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapours and toxic decomposition products. Fight fire from protected location or maximum possible distance. Dike area to prevent water runoff. Firemen should wear self-contained breathing apparatus and protective clothing.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

It is recommended to have a plan for the avoidance of spills. If spillage does occur, it has to be removed and the area cleaned immediately according to a predetermined plan. It is recommended to clean area or

equipment also if contamination is suspected.

Empty, sealable vessels for the collection of spills should be available.

In case of large spill (involving 10 tonnes of the product or more):

1. Use personal protection equipment; see section 8

2. Call emergency telephone no.; see section 1

3. Alert authorities.

Observe all safety precautions when cleaning up spills. Use personal protection equipment. Depending on the magnitude of the spill this may mean wearing respirator, face mask or eye protection, chemical

resistant clothing, gloves and boots.

Stop the source of the spill immediately if safe to do so. Keep unprotected persons away from the spill area. Avoid and reduce vapour and mist formation as much as possible. Remove sources of ignition.

Environmental precautions

Contain the spill to prevent any further contamination of surface, soil or water. Wash waters must be prevented from entering surface water drains. Uncontrolled discharge into water courses must be alerted to

the appropriate regulatory body.

Methods and materials for containment and cleaning up

It is recommended to consider possibilities to prevent damaging effects of spills, such as bunding or capping. See GHS (Annex 4, Section 6).

If appropriate, surface water drains should be covered. Minor spills on the floor or other impervious surface should be absorbed onto an absorptive material such as universal binder, attapulgite, bentonite or

other absorbent clays. Collect the contaminated absorbent in suitable containers. Clean area with much water and industrial detergent. Absorb wash liquid with absorbent and transfer to suitable containers. The

used containers should be properly closed and labelled.

Large spills which soak into the ground should be dug up and transferred to suitable containers.

Spills in water should be contained as much as possible by isolation of the contaminated water. The contaminated water must be collected and removed for treatment or disposal.

Handling and storage

In an industrial environment it is imperative to avoid all personal contact with the substance by handling and storing it only in closed systems with remote system control.

Adequate ventilation or local exhaust ventilation is required. The exhaust gases should be filtered or treated otherwise.

Avoid contact with eyes, skin or clothing. Avoid breathing vapour and avoid exposure of eyes to vapour as well.

Protect against moisture, air access and strong heat from sunshine or other source, e.g. fire.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

2734

Shipping information

Proper shipping name and description:

ADR/RID: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S.

Chemical name:

5-Chloro-8-hydroxyquinoline

Language:

English

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

2734

Shipping information

Proper shipping name and description:

IMDG: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S.

Chemical name:

5-Chloro-8-hydroxyquinoline

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

2734

Shipping information

Proper shipping name and description:

IATA: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. or POLYAMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S

Chemical name:

5-Chloro-8-hydroxyquinoline

Remarks

SpecialProvisions

Exposure controls / personal protection

When used in a closed system, personal protection equipment will not be required. The following is meant for other situations, when the use of a closed system is not possible, or when it is necessary to open the system, for example in the case of an accident. Consider the need to render equipment or piping systems non-hazardous before opening.

Wear chemical resistant gloves, such as barrier laminate, butyl rubber or nitrile rubber. The breakthrough times of these materials for this product are unknown. Generally, however, the use of protective gloves will give only partial protection against dermal exposure. Small tears in the gloves and cross-contamination can easily occur. It is recommended to shift the gloves frequently and to limit the work to be done manually.

In case of insufficient ventilation, workers should put on officially approved respiratory protection equipment with a combination filter type against acids and including particle filter and wear appropriate chemical resistant clothing to prevent skin contact.

Stability and reactivity

In case of strong heat or fire, explosive and corrosive vapors are formed. Among others hydrochloric acid vapor and nitrogen oxide vapor. Avoid strong oxidizers.

Disposal considerations

Waste treatment methods

Disposal of product or packaging

Remaining quantities of the material and empty but unclean packaging should be regarded as hazardous waste.

Disposal of waste and packagings must always be in accordance with all applicable local regulations.

According to the Waste Framework Directive (2008/98/EC), possibilities for reuse or reprocessing should first be considered. If this is not feasible, the material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing.

Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

It is recommended to consider possible ways of disposal in the following order:

1. Reuse or recycling should first be considered. If offered for recycling, containers must be emptied and triply rinsed (or equivalent). Do not discharge rinsing water to sewer systems.

2. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

3. Delivery of the packaging to a licensed service for disposal of hazardous waste.

4. Disposal in a landfill or burning in open air should only occur as a last resort. For disposal in a landfill containers should be emptied completely, rinsed and punctured to make them unusable for other purposes. If burned, stay out of smoke.