Manganese bis(phosphinate)

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

read across

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentiooned below

Principles of method if other than guideline:

Short term toxicity test was carried out for 48 hrs to study the effects of test chemical on aquatic invertebrate.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Details on test organisms:

- Common name: Water Flea
- Age of parental stock (mean and range, SD): <24 h

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

105 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: read across 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: read across 2

Conclusions:

The test chemical manganese(2+) bis(phosphinate) is not likely to be toxic to aquatic invertebrate atleast in the dose range of 100-105.0 mg/l

Executive summary:

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of manganese(2+) bis(phosphinate) (CAS: 10043-84-2) towards aquatic invertebrate is summarized as follows:

Experimental study 1 suggests that the Short term toxicity test was carried out to study the effects of test chemical on aquatic invertebrate.Effective concentration EC50 to 50% of Daphnia magna when exposed to Phosphoric acid for 48 hr is 105 mg/L. It can be concluded from the Intoxication value that the test chemical is not toxic to the aquatic invertebrateand can be considered as “not classified” as per the classification criteria for aquatic environment.

Similar supporting study 2 also suggesting that the Short term toxicity test was carried out for 48 hrs to study the effects of Manganese dioxide on aquatic invertebrate.48hr-EC50of test chemical to daphnia magna was more than100 mg/L(nominal concentration). No immobilization and adverse effects were observed. It can be concluded from the value that the test chemical is not toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally and functionally similar read across it gives the conclusion that test substance

manganese(2+) bis(phosphinate) (CAS: 10043-84-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Description of key information

Short term toxicity test was carried out to study the effects of test chemical on aquatic invertebrate.

Effective concentration EC50 to 50% of Daphnia magna when exposed to Phosphoric acid for 48 hr is 105 mg/L. It can be concluded from the Intoxication value that the test chemical is not toxic/toxic to the aquatic invertebrateand can be considered as “not classified” as per the classification criteria for aquatic environment.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

105 mg/L

Additional information

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of manganese(2+) bis(phosphinate) (CAS: 10043-84-2) towards aquatic invertebrate is summarized as follows:

Experimental study 1 suggests that the Short term toxicity test was carried out to study the effects of test chemical on aquatic invertebrate.Effective concentration EC50 to 50% of Daphnia magna when exposed to Phosphoric acid for 48 hr is 105 mg/L. It can be concluded from the Intoxication value that the test chemical is not toxic to the aquatic invertebrateand can be considered as “not classified” as per the classification criteria for aquatic environment.

Similar supporting study 2 also suggesting that the Short term toxicity test was carried out for 48 hrs to study the effects of Manganese dioxide on aquatic invertebrate.48hr-EC50of test chemical to daphnia magna was more than100 mg/L(nominal concentration). No immobilization and adverse effects were observed. It can be concluded from the value that the test chemical is not toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance

manganese(2+) bis(phosphinate) (CAS: 10043-84-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.