2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April, 1977 to August, 1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Curing agent 1115 was administered undiluted by oral intubation in a range of dosage volumes in the full scale test of 0.25 to 1.6 ml/kg bodyweight. Rats dosed with water (1.6 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All rats that died were examined macroscopically in an attempt to identify the target organs, and those
animals surviving terminally were similarly examined to detect possible residual damge.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether

EC Number:

270-846-5

EC Name:

2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether

Cas Number:

68478-97-7

Molecular formula:

C10H23BF3NO2

IUPAC Name:

2-propanamine, compd. with boron trifluoride, reaction products with butyl glycidyl

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

other: CFY

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

0.25, 0.4, 0.64, 1.0, 1.6 ml/kg

No. of animals per sex per dose:

5 animals per sex per dose

Control animals:

no

Details on study design:

Curing agent 1115 was administered undiluted by oral intubation in a range of dosage volumes in the full scale test of 0.25 to 1.6 ml/kg bodyweight. Rats dosed with water (1.6 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All rats that died were examined macroscopically in an attempt to identify the target organs, and those
animals surviving terminally were similarly examined to detect possible residual damge.

Statistics:

From the mortality data, the LD50 and its 95% confidence limits were calculated by the method Weil C.S., (1952), Biometries -8, 249.

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

0.64 mL/kg bw

Based on:

test mat.

95% CL:

> 0.47 - < 0.87

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

730 mg/kg bw

Based on:

test mat.

95% CL:

> 540 - < 990

Mortality:

Dose (ml/kg b.w.) Mortality male (deaths/dosed) Mortality female (deaths/dosed)
0.00 0/5 0/5
0.25 0/5 0/5
0.40 1/5 1/5
0.64 3/5 3/5
1.00 2/5 5/5
1.60 5/5 5/5

Clinical signs:

diarrhoea

irregular respiration

lethargy (hypoactivity)

salivation

other:

Gross pathology:

See Clinical signs section

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 of Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was determined by acute toxicity study to be 730 mg/m3.

Executive summary:

LD50 of Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was determined by acute toxicity study to be 730 mg/m3.