2-[(4-amino-3-methoxyphenyl)sulphonyl]ethyl hydrogen sulphate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal and safety asessment report

Data source

Reference

Reference 1

Reference Type:

publication

Title:

TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP

Author:

GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER

Year:

1994

Bibliographic source:

Chemosphere, Vol. 28, No. 12, pp. 2203.2236, 1994

Reference 2

Reference Type:

secondary source

Title:

7-Amino-4-hydroxy-2-naphthalenesulfonic acid

Author:

BG Chemie

Year:

2000

Bibliographic source:

BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Skin irritation test was performed on to the inner surface of ears to assess the skin irritation potential of the test substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) in two New Zealand White albino rabbits.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

7-amino-4-hydroxynaphthalene-2-sulphonic acid

EC Number:

201-718-9

EC Name:

7-amino-4-hydroxynaphthalene-2-sulphonic acid

Cas Number:

87-02-5

Molecular formula:

C10H9NO4S

IUPAC Name:

7-Amino-4-hydroxy-2-naphthalenesulfonic acid

Test material form:

solid: particulate/powder

Details on test material:

- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid

Specific details on test material used for the study:

- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Weight at study initiation: 3 – 4kg

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

500 mg

Duration of treatment / exposure:

24 hours

Observation period:

7 days

Number of animals:

2 (1/sex)

Details on study design:

TEST SITE
Area of exposure: inner surface of ears
% coverage: Not mentioned
Type of wrap if used: under an adhesive
dressing
REMOVAL OF TEST SUBSTANCE
Washing (if done): the test substance was washed off with water and soap/vegetable oil.
Time after start of exposure: after the exposure period

SCORING SYSTEM: Not mentioned

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

7 d

Score:

0

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No Irritation observed

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

In a skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was applied to the inner surface of the ears of 2 rabbits. No skin irritation was observed after 7 days. Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit skin.

Executive summary:

The skin irritation test was performed in 2 New Zealand White rabbits (male and female) to assess the skin irritation potency of test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) for the observation period of 7 days.

 

In this skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was applied to the inner surface of the ears of 2 rabbits. The test chemical was applied under an adhesive dressing for 24 hours.

 

At the end of the exposure period, the test substance was washed off with water and soap/vegetable oil. The observation period was 7 days.

 

No skin irritation was observed after 7 days.Hence the chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) can be considered non-irritant to rabbit skin.