Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 232-589-7 | CAS number: 9001-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
- Category name:
- Flammability
Justifications and discussions
- Category definition:
- All enzymes are built of different combinations of the same 20 common amino acids and thus the physical and chemical characteristics are very similar for different enzymes. Therefore, read-across from other enzymes for physical-chemical properties should be fully applicable.
- Category description:
- Cellulase and esterase, cholesterol have been tested for flammability and they had identical results: brief ignition which self-extinguished with no combustion propagation over the 2 minute test period.
- Category rationale:
- 1. CATEGORY HYPOTHESIS
All enzymes are built of different combinations of the same 20 common amino acids and thus the physical and chemical characteristics are very similar for different enzymes. Therefore, read-across from other enzymes for physical-chemical properties should be fully applicable.
2. CATEGORY JUSTIFICATION
Flammability has been determined for cholesterol, esterase and cellulase with identical results: brief ignition but the substance does not propagate combustion. Substances are not considered to be highly flammable.
3. APPLICABILITY DOMAIN OF THE CATEGORY
All enzyme substances
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