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EC number: 220-298-8 | CAS number: 2706-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 28 March 2017 Experimental completion date: 22 June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium glyoxylate
- EC Number:
- 220-298-8
- EC Name:
- Sodium glyoxylate
- Cas Number:
- 2706-75-4
- Molecular formula:
- C2H2O3.Na
- IUPAC Name:
- sodium oxoacetate
Constituent 1
- Specific details on test material used for the study:
- Identification: Safelink SPM-01
Appearance/Physical state: colorless to slightly yellow powder
Batch: G150201
Purity: 99.9%
Expiry date: not supplied
Storage conditions: room temperature, in the dark
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.2
- Temp.:
- 22 °C
- pH:
- 6.8
- Details on results:
- Preliminary Estimate
The log10 Pow was calculated to be: -5.21
Discussion
The determination of partition coefficient was performed using the shake-flask method. This
was due to the expected partition coefficient obtained in the preliminary assessment.
The stock solution was prepared in n-octanol saturated water in place of water saturated
n-octanol. This was due to the insolubility of the test item in the organic phase. This issue
has been considered to have had a negligible impact on the overall result and has been
considered to be more appropriate to obtain a realistic partition coefficient value.
As there was no definitive test item detected in the organic phases, a limit valve for the
sample concentrations was taken based on the organic phase sample with the highest
absorbance. This result was corrected for the absorbance of the organic phase matrix blank
extract. This approach provided a worst case scenario and resulted in the final result being a
limit value. Although the test item was a complex mixture, it is considered that the test result
represents the test item as a whole.
Validation
The linearity of the detector response with respect to concentration was assessed over the
nominal concentration ranges of 5 to 50 mg/L (organic phases) and 50 to 500 mg/L (aqueous
phases). The results were satisfactory with a correlation coefficient (r) of 0.998 and 0.999
being obtained respectively.
Any other information on results incl. tables
Results
The partition coefficient determined for each flask is shown in the following table:
Flask | Organic/ Aqueous Volume Ratio |
Partition Coefficient | Log10 Pow | Mean Partition Coefficient |
1 | 02:01 | ≤6.00 x 103 | ≤2.22 | ≤2.22 |
2 | ≤5.98 x 103 | ≤2.22 | ||
3 | 04:01 | ≤5.82 x 103 | ≤2.24 | ≤2.22 |
4 | ≤6.08 x 103 | ≤2.22 | ||
5 | 08:01 | ≤6.02 x 103 | ≤2.22 | ≤2.22 |
6 | ≤6.30 x 103 | ≤2.22 |
Overall Pow : ≤6.30 x 10-3
Overall log10 Pow : ≤2.20
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item has been determined to be less than or equal to be
6.30 x 10-3 at 22.0 ± 0.5 °C, log10 Pow of ≤2.20. - Executive summary:
Less than or equal to be 6.30 x 10-3 at 22.0 ± 0.5 °C,
log10 Pow of ≤2.20, using the shake-flask method, designed to be compatible with Method A.8
Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and
Method 107 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
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