Registration Dossier
Registration Dossier
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EC number: 236-060-1 | CAS number: 13126-12-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Paper written in Russian
Data source
Reference
- Reference Type:
- publication
- Title:
- Paper written in Russian
- Author:
- Khamidulina
- Year:
- 1 987
- Bibliographic source:
- Public domain
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- Russian paper
- Principles of method if other than guideline:
- Paper publicly available and written in Russian by the team of Khamidulina.
- GLP compliance:
- no
Test material
- Reference substance name:
- Rubidium nitrate
- EC Number:
- 236-060-1
- EC Name:
- Rubidium nitrate
- Cas Number:
- 13126-12-0
- Molecular formula:
- HNO3.Rb
- IUPAC Name:
- Rubidium nitrate
- Test material form:
- solid: crystalline
- Remarks:
- powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Paper written in Russian
Test system
- Type of coverage:
- other: Paper written in Russian
- Preparation of test site:
- other: Paper written in Russian
- Vehicle:
- other: Paper written in Russian
- Amount / concentration applied:
- Paper written in Russian
- Duration of treatment / exposure:
- Paper written in Russian
- Observation period:
- Paper written in Russian
- Number of animals:
- Paper written in Russian
- Details on study design:
- Paper written in Russian
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Paper published in Russian
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- From a paper publicly available and written in Russian by the team of Khamidulina, rubidium nitrate does not induce local effect and has demonstrated a skin resorption effect on rat. Same study was also conducted on rubidium sulfate, rubidium carbonate and rubidium chloride. All of these substance were not irritant.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From a paper publicly available and written in Russian by the team of Khamidulina (1987), rubidium nitrate does not induce local effect and has demonstrated a skin resorption effect on rat.
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