Registration Dossier
Registration Dossier
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EC number: 947-387-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The acute toxicity to fish (Oncorhynchus mykiss) of DMAPSA (Octadecanamide, N-(3-(dimethylamino)propyl)-) was evaluated.
A preliminary test on series of two fishes indicated that no mortality was expected for a test item concentration of 0.1 mg/L after a period of 4 days. Mortality was however observed for the two individuals at test item concentrations of 1 and 10 mg/L.
A definitive study was carried out on two series of 10 individuals with a concentration of 0.1 mg/L of test item for a period of 4 days. Two repetitions were performed. No mortality was observed.
Based on these results, it was concluded that the 96-hour LC50 value for acute toxicity to fish of DMAPSA (Octadecanamide, N-(3-(dimethylamino)propyl)-) is between 0.1 and 1 mg/L. According to the Guidance on the Application of the CLP criteria (Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017), DMAPSA should therefore be classified as Very Toxic to Aquatic Life (H400, Aquatic acute Category 1) based on the CLP regulation criteria, with an M-factor of 1.
Respiration inhibition of DMAPSA (Octadecanamide, N-(3-(dimethylamino)propyl)-) on activated sludge was studied. The activated sludge was subjected to various concentrations of test substance for 3 consecutive hours.
A preliminary study was carried out with test substance concentrations of 1, 10, 100 and 1000 mg/L.
Based on the results obtained in this preliminary test, it was decided to make new measurements on 100 mg/L replicates.
No significant respiration inhibition was found based on the 100 mg/L replicates.
The EC50 for respiration inhibition of activated sludge by DMAPSA after 3 hours of exposure was therefore determined to be > 100 mg/L.
Additional information
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