Registration Dossier
Registration Dossier
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EC number: 258-420-7 | CAS number: 53185-52-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 October 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- other: Reference to HPLC-UV analytical method for quantitative analysis of the water samples
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Because the substance was expected to be miscible with water, a solubility test was performed. No guideline test method (flask or column elution) was conducted.
- GLP compliance:
- yes
- Type of method:
- other: solubility test
- Key result
- Water solubility:
- > 500 g/L
- Temp.:
- 21.5 °C
- pH:
- >= 9.7 - <= 9.73
- Details on results:
- The test mixtures were observed to be homogeneous solutions without any undissolved test material.
Concentrations analysed (mean of duplicate analysis):
Mixture 1: 506 g/L
Mixture 2: 499 g/L
Mixture 3: 496 g/L
Mean: 500 g/L (i.e. 100% relative to the nominal concentration) - Conclusions:
- The water solubility of the substance at 21.5°C is > 500 g/L.
- Executive summary:
In a water solubility test at 21.5°C, three mixtures of the substance in water (500 g/L nominal) were observed to be homogeneous solutions without any undissolved test material.
The mean substance concentration analysed in the mixtures was 500 g/L. The pH of the mixtures was 9.7. The water solubility of the substance at 21.5°C was concluded to be > 500 g/L. No guideline test method (flask or column elution) was conducted.
Reference
Description of key information
Water solubility at 21.5°C: > 500 g/L (visual observation, no guideline followed).
Key value for chemical safety assessment
- Water solubility:
- 500 g/L
- at the temperature of:
- 21.5 °C
Additional information
Three mixtures of the substance in water (500 g/L nominal) were observed to be homogeneous solutions without any undissolved test material. The pH of the aqueous mixtures was 9.7.
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