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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,3,3-tetrafluoropropan-1-ol
EC Number:
200-955-5
EC Name:
2,2,3,3-tetrafluoropropan-1-ol
Cas Number:
76-37-9
Molecular formula:
C3H4F4O
IUPAC Name:
2,2,3,3-tetrafluoropropan-1-ol
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no details reported

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no details reported
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
no details reported
Statistics:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
3 400 mg/kg bw
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 400 mg/kg bw
Remarks on result:
not measured/tested
Remarks:
LD50 > LDlo
Mortality:
not reported
Clinical signs:
other: Respiratory impairment, gastric irritation, narcosis, incoordination, and prostration
Gross pathology:
not reported

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 in the rat is greater than 3400 mg/kg bw, which was reported as "approximate lethal dose".