Ethyl palmitate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read across category

Justification for type of information:

See attached document in section 0"Categries" and section 13 "Assessment reports" for justification and rationale for category approach.

Key result

Water solubility:

< 0.15 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 6.4

Table 1: Results from key studies performed on the source substances of the category

Common name	CAS	Fatty acid  chain length	Type of alcohol	MW	Appareance	Water Solubility
Isopropyl myristate	110-27-0	C14	Isopropanol	270,46	Liquid	Experimental result: <0.05 mg/L at 20 °C
Isopropyl palmitate	142-91-6	C16	Isopropanol	298.51	Liquid	no data
Ethyl linoleate	544 -35-4	C18:2	ethanol	308,5	Liquid	no data
Ethyl oleate	111-62-6	C18:1	ethanol	310.52	Liquid	no data
Fatty acids, C16-18, butyl esters	85408-76-0	C16-18	Butanol	312.53 – 340.58	Paste	Experimental result: <0.05 mg/L at 20 °C
Fatty acids, C16-18 and C18-unsatured, isobutyl esters	84988-79-4	C16-18, C18:1	Isobutanol	312.53 – 340.58	Liquid	Experimental result: <0.15 mg/L at 20 °C
Isopropyl isostearate	68171-33-5	C18iso	Isopropanol	326.56	Liquid	Experimental result: <0.15 mg/L at 20 °C

 

The physical-chemical properties of the category members are similar or follow a regular pattern over the category. Several members of the category have been tested for their water solubility. The tested substances represent different fatty acid chain lengths, C14, C16 and C18 or C18unsat.,combined with different alcohols,  isopropanol, butanol or isobutanol.  

Experimental results were obtained for several category members which all show water solubility less than 0.15 mg/L or less than 0.05 mg/L depending on the limit of detection of the analytical method. These similar results are related to the similarity of structures of the category members, and specifically to the presence of long fatty acid chains which confer hydrophobic properties.

Based on the structural similarities between the target and the sources chemicals, water solubility for the target substance was defined to be less than 0.15 mg/L at 20°C and "Ethyl palmitate” was considered to have a  low water solubility.

Conclusions:

Based on the results from studies performed on source chemicals of the category, the water solubility of the source substances was defined to be less than 0.15 mg/L. According to the category approach, this water solubility value < 0.15 mg/L could be attributed to the target substance Ethyl palmitate. Hence, Ethyl palmitate was considered to have a low solubility in water.

Description of key information

Based on the structural similarities between the target and the sources chemicals, the water solubility for the target substance Ethyl Palmitate was defined to be less than 0.15 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:

0.15 mg/L

at the temperature of:

20 °C

Additional information

Several members of the category have been tested for their water solubility. The tested substances (isopropyl myristate; fatty acids C16 -18 butyl esters; fatty acids C16 -18, C18 unsat. isobutyl ester; isopropyl isostearate) show water solubility less than 0.15 mg/L or less than 0.05 mg/L depending on the limit of detection of the analytical method. These similar results are related to the similarity of structures of the category members, and specifically to the presence of long fatty acid chains which confer hydrophobic properties. On the basis of a category approach, the water solubility of the target substance was defined to be less than 0.15 mg/L at 20°C and "Ethyl palmitate” was considered to have a  low water solubility.