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EC number: 612-722-9
CAS number: 61931-07-5
LD50 (oral, rat) > 5000 mg/kg bw
Acute oral toxicity
An acute oral toxicity study was performed
treatingfive male and five female rats with test substance. The study
was conducted according to the recommendation of the OECD Guideline 401
(1981). No death occurred after a single administration of 5000 mg/kg
which corresponds to the maximum administrable dose level.
A slight hypokinesia was observed after
treatment but the behaviour and body weight gain of the animals were not
influenced by the treatment.
The macroscopic investigations revealed no
lesion in the animals sacrificed at the end of the observation period.
The oral LD50 value of the substance in
rats was established to exceed 5000 mg/kg bw.
In the CLP Regulation (EC 1272/2008) acute
toxicity is defined as “those adverse effects occurring following oral
or dermal administration of a single dose of a substance or a mixture,
or multiple doses given within 24 hours, or an inhalation exposure of 4
hours”. A substance can be allocated to one of four toxicity categories
based on acute toxicity by the oral, dermal or inhalation route. The
numeric criteria based on the acute toxicity estimates (ATE) in mg/kg
bodyweight are presented in Annex I, Part 3, Table 3.1.1. For acute oral
toxicity: "Category 4: 300 < ATE ≤ 2 000".
Based on the available experimental data
of acute oral toxicity (LD50 > 5000 mg/kg bw), no classification for
acute oral toxicity is warranted under the CLP Regulation (EC 1272/2008).
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