Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Lange's Handbook of Chemistry, 13th ed.
Author:
Dean, J.A., Ed.
Year:
1985
Bibliographic source:
Lange's Handbook of Chemistry, 13th ed., Dean, J.A., Ed., McGraw-Hill (New York, NY: 1985), pp. 5-52.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Perr Review Data, guideline not specified.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyruvic acid
EC Number:
204-824-3
EC Name:
Pyruvic acid
Cas Number:
127-17-3
Molecular formula:
C3H4O3
IUPAC Name:
2-oxopropanoic acid
Test material form:
liquid

Results and discussion

Dissociating properties:
yes
Dissociation constant
No.:
#1
pKa:
2.49
Temp.:
25 °C

Applicant's summary and conclusion

Conclusions:
The dissociation constant for acetic acid is pKa = 2.49.
Executive summary:

This information is taken from a reliable peer reviewed handbook and so can be considered reliable and suitable for use as the key study for this endpoint.