Registration Dossier
Registration Dossier
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EC number: 911-418-6 | CAS number: 55965-84-9
Endpoint summary
Administrative data
Description of key information
Two OECD 404 guideline compliant studies are provided indicating CMIT/MIT is corrosive to the skin.
An in vivo eye irritation study is presented indicating CMIT/MIT is corrosive to the eyes.
An airway irritation study (ASTM Method E981 -84) is presented indicating CMIT/MIT is irritating to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
C(M)IT/MIT is severely irritant to corrosive to the skin and eyes of rabbits in the different studies submitted.
Regarding the irritation of airways, a concentration of 69 μg/l of Kathon 886F induced a 50% reduction in the respiratory rate in mice (RD50).
Justification for classification or non-classification
CMIT/MIT has an existing harmonized classification in accordance with Annex VI Regulation EC 1272/2008 as:
Skin Corr. 1B/H314: Causes severe skin burns and eye damage C ≥ 0.6%
Eye Irrit. 2; H319: Causes serious eye irritation/Skin Irrit. 2; H315: Causes skin irritation 0.06% ≤ C < 0.6%
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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