ColaLiquids DC5, DL, DM (Commercial names)Cocamide DIPA (INCI name)

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

assessment report

Reason / purpose for cross-reference:

assessment report

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

The water solubility of Cocamide DIPA was attempted to be measured according to OECD test method TG 105, but was unable to be measured due to the physical properties of the mixture in that it was apparent that some constituents of the UVCB are more soluble in water than other constituents and a clear solution was difficult to obtain. After several attempts, dispersions were obtained.

Deviations:

yes

Remarks:

visual inspection of solutions and confirmation by HPLC from the ecotoxicity reports

Principles of method if other than guideline:

The water solubility of Cocamide DIPA was attempted to be measured according to OECD test method TG 105, but was unable to be measured due to the physical properties of the mixture in that it was apparent that some constituents of the UVCB are more soluble in water than other constituents and a clear solution was difficult to obtain. After several attempts, dispersions were obtained.
However, even when there was apparent undissolved material, it was clear that a significant part of the substance does dissolve in water. This was confirmed thy Ecotoxicity testing where a stock solution of 1000 mg/l was not clear in water, but 100 mg/l was only slightly hazy. Confirmation of dissolution was carried out by HPLC analysis
For the purposes of ecotoxicity testing, solubility was considered to be approximately 100 mg/l and was clear that a substantial part of the substance was soluble in excess of 100 mg/l. Laboratory records suggest 100 mg/l was 'virtually clear'. There was also a dose response in algae up to 100 mg/l implying that saturation is > 100 mg/l.
For purposes of the CSA and to provide a minimum figure for estimation of comparative solubilities of the substance in water and octanol, the nominal figure of 100 mg/l seems appropriate.

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

Cola®Liquid DC-5 (lot 58039G17)

Water solubility:

ca. 100 mg/L

Conc. based on:

test mat.

Remarks on result:

other: estimated based on information from ecotoxicity testing

Conclusions:

Due to the liquid surfactant nature of the Cocamide DIPA it is not possible to determine the water solubility of the substance using the standard OECD 105 test method. A result of ca 100 mg/l has been established based on the fact that for the purposes of ecotoxicity testing, solubility was considered to be approximately 100 mg/l and was clear that a substantial part of the substance was soluble in excess of 100 mg/l. Laboratory records suggest 100 mg/l was 'virtually clear'. There was also a dose response in algae up to 100 mg/l implying that saturation is > 100 mg/l.  For purposes of the CSA and to provide a minimum figure for estimation of comparative solubilities of the substance in water and octanol, the nominal figure of 100 mg/l seems appropriate.

Description of key information

Due to the liquid surfactant nature of the Cocamide DIPA it is not possible to determine the water solubility of the substance using the standard OECD 105 test method. A result of ca 100 mg/l has been established based on the fact that for the purposes of ecotoxicity testing, solubility was considered to be approximately 100 mg/l and was clear that a substantial part of the substance was soluble in excess of 100 mg/l. Laboratory records suggest 100 mg/l was 'virtually clear'. There was also a dose response in algae up to 100 mg/l implying that saturation is > 100 mg/l.  For purposes of the CSA and to provide a minimum figure for estimation of comparative solubilities of the substance in water and octanol, the nominal figure of 100 mg/l seems appropriate.

Key value for chemical safety assessment

Water solubility:

100 mg/L

at the temperature of:

20 °C