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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

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Category name:
Enzymes - Biodegradation

Justifications and discussions

Category definition:
Enzymes are readily biodegradable.
Category rationale:
REPORTING FORMAT FOR THE CATEGORY APPROACH
[Please provide information for all of the points below. Should you wish to add supporting documents, please attach the document(s) in the field 'Reports', and indicate this in the appropriate point.]

1. CATEGORY HYPOTHESIS
Enzymes and other proteins are polymers built of different combinations of the 20 common amino acids. The sequence and length of the amino acids in the polymer differ between enzymes, and this determines the 3-dimensional structure, the activity and specificity of the enzyme. The physico-chemical characteristics of enzymes are mainly dependent on the amino acids building the enzyme. Since all enzymes are built up of a combination of the same 20 common amino acids, the physical and chemical characteristics will be very similar across different enzymes, but also degradability.

2. CATEGORY JUSTIFICATION
A variety of enzyme classes has been tested for biodegradability and all prove to be readily biodegradable according to OECD 301.

3. APPLICABILITY DOMAIN OF THE CATEGORY
Enzymes