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EC number: 255-002-6 | CAS number: 40615-36-9
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-01-19 to 2018-02-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- agglomerate
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 12.8 µm
- Percentile:
- D50
- Mean:
- 12.8 µm
- Remarks on result:
- other: Standard deviation not reported
- Percentile:
- D10
- Mean:
- 4 µm
- Remarks on result:
- other: Standard deviation not reported
- Percentile:
- D90
- Mean:
- 383.5 µm
- Remarks on result:
- other: Standard deviation not reported
- Conclusions:
- The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering):
Average of the median particle size D (v, 0.5): 12.8 µm
Average of the particle size D (v, 0.1): 4.0 µm
Average of the particle size D (v, 0.9): 383.5 µm - Executive summary:
The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering). A large part of the test item was present as agglomerates with a diameter above 1 mm. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.
Average of the median particle size D (v, 0.5): 12.8 µm
Average of the particle size D (v, 0.1): 4.0 µm
Average of the particle size D (v, 0.9): 383.5 µm
Reference
The test item consisted of non-transparent particles which had a very strong tendency for agglomeration. The particles had a sticky behaviour and were electrostatically charged after sieving. A large part of the test item was present in form of agglomerates with a diameter above 1 mm. The aforementioned effects opposed a measurement via sieve analysis and influenced the results of the study using laser diffraction. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.
Median particle size D (v, 0.5): 50% of particle volume or particle mass with lower particle diameter
1st test series: 11.8 µm
2nd test series: 13.9 µm
Average of median particle size: 12.8 µm
Particle size D (v, 0.1): 10% of particle volume or particle mass with lower particle diameter
1st test series: 3.8 µm
2nd test series: 4.2 µm
Average of the particle size: 4.0 µm
Particle size D (v, 0.9): 90% of particle volume or particle mass with lower particle diameter
1st test series: 327.9 µm
2nd test series: 439.1 µm
Average of the particle size: 383.5 µm
The particle size showed a polymodal distribution. Maxima were observed at approximately 0.8 µm, 8 µm, 80 µm and 400 µm. The maxima at 400 µm and 80 µm most likely corresponded to agglomerates.
Description of key information
The particle size distribution of the test item 4,4’-Dimethoxytrityl chloride was determined by laser diffraction (light scattering). A large part of the test item was present as agglomerates with a diameter above 1 mm. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.
Average of the median particle size D (v, 0.5): 12.8 µm
Average of the particle size D (v, 0.1): 4.0 µm
Average of the particle size D (v, 0.9): 383.5 µm
Additional information
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