(1R,2R,4S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference Type:

publication

Title:

Fragrance material review on fenchyl alcohol

Author:

Bhatia S P

Year:

2008

Bibliographic source:

Food and Chemical Toxicology, 46 (2008), pp 157-159

Materials and methods

Principles of method if other than guideline:

No data on test method

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,3-dimethyl-8,9-dinorbornan-2-ol

EC Number:

216-639-5

EC Name:

3,3-dimethyl-8,9-dinorbornan-2-ol

Cas Number:

1632-73-1

Molecular formula:

C10H18O

IUPAC Name:

1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

2050, 2560, 3200, 4000 and 5000 mg/kg bw.

No. of animals per sex per dose:

2 animals for doses of 2050, 2560 and 4000 mg/kg bw
3 animals for dose of 3200 mg/kg bw
5 animals for dose of 5000 mg/kg bw

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 050 mg/kg bw

Based on:

test mat.

Mortality:

All deaths occurred between days 1 and 3.
At 2050 and 2560 mg/kg bw, 1/2 animals died; 3/3 animals died at 3200 mg/kg bw; 2/2 animals died at 4000 mg/kg bw and 5/5 animals died at 5000 mg/kg bw.

Clinical signs:

other: Clinical signs included lethargy, ataxia, tearing, comatose and flaccid (no further details were reported).

Applicant's summary and conclusion

Interpretation of results:

other: Not classified (CLP Regulation EC no. 1272/2008)

Conclusions:

The acute oral LD50 value of the test substance was found to be 2050 mg/kg bw in rats.

Executive summary:

The acute oral toxicity of the test item was evaluated in rats. The test substance was administered at dose levels of 2050, 2560, 3200, 4000, and 5000 mg/kg body weight. Mortality and clinical observations were analyzed for 14 days after exposure. All deaths occurred between days 1 and 3. At 2050 and 2560 mg/kg bw, 1/2 animals died; 3/3 animals died at 3200 mg/kg bw; 2/2 animals died at 4000 mg/kg bw and 5/5 animals died at 5000 mg/kg bw. Clinical signs included lethargy, ataxia, tearing, comatose and flaccid. The acute oral LD50 value of the test substance was determined to be 2050 mg/kg bw.