Registration Dossier
Registration Dossier
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EC number: 208-634-1 | CAS number: 536-45-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue justification attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 943 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (48 h) = 943 mg/L for D. magna (OECD 202)
- Executive summary:
No data are available on the toxicity of sodium anisate (CAS No. 536-45-8) to Daphnia magna. Therefore data from the analogue substance were used as read across.
The acute toxicity of the test item to aquatic invertebrates was investigated in a study by Kamaya et al. (2005). Daphnia magna was exposed for 48 hours to the test material at nominal concentrations of 2 (304.3 mg/L) to 12 mmol/L (1825.8 mg/L). Samples from all concentrations and the control was checked before and after (48 h) exposure experiments by the UV spectra (400–200 nm). The EC50 (48 h) was determined at 943 mg/L.
Reference
Description of key information
EC50 (48 h) = 943 mg/L (publication, Daphnia magna, nominal, read-across)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 943 mg/L
Additional information
No data are available on the on the toxicity of sodium anisate (CAS No. 536-45-8) to aquatic invertebrates. Therefore data from the analogue substance p-anisic-acid (CAS No. 100-09-4) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
The acute toxicity of the test item to aquatic invertebrates was investigated in a study by Kamaya et al. (2005). Daphnia magna was exposed for 48 hours to the test material at nominal concentrations of 2 mmol/L (304.3 mg/L) to 12 mmol/L (1825.8 mg/L). Samples from all concentrations and the control was checked before and after (48 h) exposure experiments by the UV spectra (400–200 nm). The EC50 (48 h) was determined at 943 mg/L.
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