Registration Dossier
Registration Dossier
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EC number: 423-630-1 | CAS number: 62435-71-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In the bacterial genemutation test, there was a weak positive response in TA 100 and TA 1535 at highest concentrations only, without S-9. The study was repeated three times (only with TA100 and TA 1535 in two repeats) and both marginal positive and negative results were seen.
The mouse lymphoma (TK) assay resulted in slight,but significant, positive without S-9 at high concentrations only.
In-vivo UDS study also negative
This result implies low concentrations of potential genotoxic substance as impurity or metabolite
Note that key metabolite acetaldehyde presents as a positive genotoxic substance in the absence of S-9, and this result implies traces of acetaldehyde are present, but in the presence of enzyme metabolism, this is negated to form acetates and non-hazardous further metabolites.
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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