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Administrative data

Endpoint:
flash point of flammable liquids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 June 2017 - 14 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.9 (Flash-Point)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: United Nations (UN), UN no. ST/SG/AC.10/11/Rev.6, Part III, Paragraph 32.4.1: “Non-Viscous Flammable Liquids”
Deviations:
no
Qualifier:
according to guideline
Guideline:
ASTM D93 (Standard test methods for flash point by pensky-martens closed cup tester)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: ASTM International, ASTM D7094: “Standard Test Method for Flash Point by Modified Continuously Closed Cup (MCCCFP) Tester”, 2012
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 2719 (Determination of flash point - Pensky-Martens closed cup method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 3679 (Determination of flash point - Rapid equilibrium closed cup method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
closed cup
Flash point apparatus:
other: Eraflash flash-point

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorophenyl cyclopentyl ketone
EC Number:
229-802-0
EC Name:
2-chlorophenyl cyclopentyl ketone
Cas Number:
6740-85-8
Molecular formula:
C12H13ClO
IUPAC Name:
2-chlorophenyl cyclopentyl ketone
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study reports): JNJ-54582034-AAA (T003642)
- Physical state: liquid
- Appearance: yellow liquid
Specific details on test material used for the study:
- Batch n°: I16KB4361
- Analytical purity: 98.4% (HPLC assay)
- Test item storage: In refrigerator (2-8°C), container flushed with argon
- Stable under storage conditions until: 19 Sep 2017 (retest date)

Results and discussion

Flash point
Key result
Flash point:
128 °C
Atm. press.:
1 013.25 hPa

Any other information on results incl. tables

 Preliminary test

The estimated flash-point of the test item was 117°C.

 

Main study

The results of the main study on the determination of the flash-point of the test item are given in the table below.

 

The difference between the results obtained with test 2 and 3 was ≤6°C. From this, it was concluded that the flash-point of the test item is the lowest flash-point obtained. 

 Test  Flash-point [°C]  Lowest flash-point [°C]
 2  128  128
 3  132  128

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The closed cup method was applied for the determination of the flash-point of JNJ-54582034-AAA (T003642).
The flash-point of the test item was 128°C.