Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 816-325-3 | CAS number: 5436-05-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 27 September 2017 to 06 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.108 mg/L
- Temp.:
- 20 °C
- pH:
- > 5.8 - < 6
- Water solubility:
- > 0.103 - < 0.114 mg/L
- Temp.:
- 20 °C
- pH:
- 5.8
- Water solubility:
- > 0.104 - < 0.111 mg/L
- Temp.:
- 20 °C
- pH:
- 6
- Details on results:
- In the preliminary test, the content of test item dissolved in the water sample was <10mg/l
- Conclusions:
- The water solubility of the test item is 0.108 mg/l at 20°C and pH between 5.8 up to 6.0
- Executive summary:
The water solubility of
the test item was determined according to recognised guidelines and under GLP. No deviation from the guideline was observed during the study.
Based on the results obtained in the preliminary test, the column elution method was used for the test item water solubility measurement.
The water solubility of the test item is 0.108 mg/l at 20°C and pH between 5.8 up to 6.0
Reference
The coefficient of variation at each flow rate was lower than 30%. It was demonstrated that the system was equilibrated at all flow rates.
The maximum difference on the mean values of the samples at both flow rates was also lower than 30%. Based on this, the water solubility of the test item is given as the means value of these measurements.
The turbidity of the eluates was lower than 0.2 NTU. According to this, no undissolved particles were detected in the eluates. No test item was detected in the samples from the blank column.
Description of key information
The water solubility of the test item was detemined in a key study of Klimisch validity 1 performed according to recognised guidelines and in compliance with GLP (Brekelmans, 2018).
No deviation from the guideline was observed in the study.
Key value for chemical safety assessment
- Water solubility:
- 0.108 mg/L
- at the temperature of:
- 20 °C
Additional information
Based on the water solubility at 20°C, the test item is considered as slightly soluble.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
