Registration Dossier
Registration Dossier
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EC number: 268-799-0 | CAS number: 68140-48-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl]ethan-1-one
- EC Number:
- 268-799-0
- EC Name:
- 1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl]ethan-1-one
- Cas Number:
- 68140-48-7
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1-[1,1,2,6-tetramethyl-3-(propan-2-yl)-2,3-dihydro-1H-inden-5-yl]ethan-1-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intacted and abraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- scintillated
- Observation period:
- 24 and 72 h
- Number of animals:
- 6 intacted skin group and 6 abraded skin group
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 4.2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.5
- Max. score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: abraded skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
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