Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-481-4 | CAS number: 96-14-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test substance was applied within a glass ring to the volar forearm of a volunteer and left on the skin for 5 min.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-hexane
- EC Number:
- 203-777-6
- EC Name:
- N-hexane
- Cas Number:
- 110-54-3
- Molecular formula:
- C6H14
- IUPAC Name:
- hexane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- n-hexane, analytical grade
Test animals
- Species:
- other: human
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- single dose, 1.5 ml on an area of 3.1 cm²
- Duration of treatment / exposure:
- 5 min.
- Observation period:
- 60 min.
- Number of animals:
- 1 human volunteer
Results and discussion
In vivo
Results
- Irritation parameter:
- other: visual inspection
- Time point:
- other: 10-20 minutes
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Remarks:
- A slight transient erythema was observed after 10-20 minutes exposure to 1.5 mL n-hexane. Stinging and/or burning sensation reported by the volunteer. Application of 0.1 mL neat n-hexane did not cause clinical signs or affect blood flow.
- Irritant / corrosive response data:
- increased blood flow, slight erythema, stinging and/or burning sensation
fully reversible within 60 min.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Analogue substance n-hexane caused fully reversible skin irritation at a human volunteer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
