Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
intramuscular injection
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Antitumor activities of some Schiff bases
Author:
Hodnett, Ernest M.; Mooney, Paul D.
Year:
1970
Bibliographic source:
Journal of Medicinal Chemistry (1970) Vol. 13, No. 4, pp. 786.

Materials and methods

Principles of method if other than guideline:
Single intramuscular injection to Walker sarcomas of rats
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
EC Number:
212-975-1
EC Name:
1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
Cas Number:
894-93-9
Molecular formula:
C17H13NO2
IUPAC Name:
1-[(1E)-[(2-hydroxyphenyl)imino]methyl]naphthalen-2-ol

Test animals

Species:
rat

Administration / exposure

Route of administration:
intramuscular
Doses:
400 mg/kg bw

Results and discussion

Mortality:
Not specifically mentioned. Since the dose was used to determine antitumor-activity, it is presumed to be non-lethal.
Other findings:
Tumor size was reduced to 78% after injection with the test substance.

Applicant's summary and conclusion