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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
1 000 g/L
Conc. based on:
test mat.
Remarks on result:
other: test performed at room temperature. No exact value available.
Details on results:
The method used yielded reliable results, based on chromatograms with UV detection.
A one day old and a freshly prepared saturated solution were prepared for quantitation to control and to confirm the results of the three day experiment according to OECD Method 105.
The experiment according to the OECD method showed less than 3% difference in the concentrations on three consecutive days (acceptance criteria 15 %).
The control experiment yielded a difference of only 6%.
The solubility of Dipotassium malonate in water was established as 1.00 g/mL on the 3rd day of the experiment.

Sample ID

Nominal Concentration g/mL

Calculated Concentration μg/mL

Dilution Factor Test-Site

Mean Final Conc. g/mL*

Mean g/mL*

3rdday

1.00

105.5

10000

0.987

3rdday

1.00

95.15

10000

1.00

2ndday

1.00

100.7

10000

2ndday

1.00

95.81

10000

0.982

1stday

1.00

98.03

10000

1stday

1.00

96.78

10000

0.974

Control 24 h

1.10

103.5

10000

1.06

Control 24 h

1.10

102.8

10000

1.03

Control 0 h

1.10

112.6

10000

Control 0 h

1.10

104.9

10000

1.09

Conclusions:
The water solubility of dipotassium malonate was determined to be 1.00 g/mL (= 1000 g/L)
Executive summary:

The water solubility of dipotassium malonate was assessed by the shake flask method in line with OECD guideline 105.

The test concentration in a saturated solution as determined by means of HPLC was found to be 1.00 g/mL.

Description of key information

Key value for chemical safety assessment

Water solubility:
1 000 g/L

Additional information