Concrete of Salvia sclarea L. (Lamiaceae) obtained from leaves, flowers and twigs by apolar hydrocarbon solvent extraction with or without purification by molecular distillation

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 July 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2009

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on 13 and 14 October 2014 / signed on 08 April 2015

Type of method:

static method

Key result

Temp.:

20 °C

Vapour pressure:

434 Pa

Key result

Temp.:

25 °C

Vapour pressure:

536 Pa

Table 4.6/1: Measurement Values

1. Determination increasing temperature			2. Determination decreasing temperature
Temp. in °C	Date/Time	Pressure in hPa*	Temp. in °C	Date/Time	Pressure in hPa*
20.0	25. July 2017 / 10:00	4.2	47.5	25. July 2017 / 14:05	12.6
29.0	25. July 2017 / 10:50	6.5	37.9	25. July 2017 / 14:34	9.1
38.0	25. July 2017 / 11:40	9.2	28.5	25. July 2017 / 14:49	6.2
47.0	25. July 2017 / 12:30	12.3	21.0	25. July 2017 / 15:15	4.6
56.1	25. July 2017 / 13:20	17.2	16.0	25. July 2017 / 15:35	3.6

The calculation results are presented in the following table:

Table 4.6/2: Calculated values for 1/T and log P 

n	Temperature T	Pressure P	Temperature T	1/T	log P
	°C	hPa*	K	1/K	log Pa
1	20.0	4.2	293.15	0.00341122	2.6232
2	29.0	6.5	302.15	0.00330961	2.8129
3	38.0	9.2	311.15	0.00321388	2.9638
4	47.0	12.3	320.15	0.00312354	3.0899
5	56.1	17.2	329.25	0.00303721	3.2355
6	47.5	12.6	320.65	0.00311867	3.1004
7	37.9	9.1	311.05	0.00321492	2.9590
8	28.5	6.2	301.65	0.00331510	2.7924
9	21.0	4.6	294.15	0.00339963	2.6628
10	16.0	3.6	289.15	0.00345841	2.5563

*hPa = mbar

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Table 4.6/3.- Linear Regression Parameters

Parameter	Value
Slope	-1603.177429
Intercept	8.106333397
Correlation coefficient r	-0.999244365
Coefficient of determination r^2	0.99985

 

Table 4.6/4 .- Calculated Values for vapour pressure

Parameter	Value	Unit
Vapour Pressure (20 °C)	434	Pa
Vapour Pressure (25 °C)	536	Pa

Discussion

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 434 Pa at 20.0 °C and 536 Pa at 25 °C.

The values of the heating and cooling down phase showed good correspondence (the coefficient of determination (r²) is greater than 0.95)

Therefore, the result of the study is considered valid.

Conclusions:

The vapour pressure of the test item was calculated as 434 Pa at 20 °C and 536 Pa at 25 °C.

Executive summary:

The vapour pressure of the test item was measured under GLP using the static method as described in EU method A.4 and OECD 104.

Ten determinations of vapour pressure were performed in a temperature range of 16.0 – 56.1 °C and the pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be interpolated.

Finally, the vapour pressure of the test item was calculated as 434 Pa at 20 °C and 536 Pa at 25 °C.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).

Description of key information

The vapour pressure of the test item was calculated as 434 Pa at 20°C and 536 Pa at 25 °C (interpolation).

Key value for chemical safety assessment

Vapour pressure:

536 Pa

at the temperature of:

25 °C

Additional information

A reliable experimental study conducted according to a recognized OECD/EC method and under GLP, is available.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).