1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Endpoint summary

Description of key information

A sample of the test item was tested for skin irritation potential according to the procedure prescribed by the Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41. 0.5 g of the sample was mixed with 0.5 ml of distilled water before application to the skin of tested rabbits.

For the eye irritation testing, the procedure employed was that prescribed by The Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.42. 79 mg of sample was instilled into one eye of each six rabbits, while the untreated eye was used as concurrent control. 

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1976

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: limited justification

Qualifier:

according to guideline

Guideline:

other: Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41

GLP compliance:

no

Specific details on test material used for the study:

Sample code n°: 507-43

Species:

rabbit

Strain:

other: Albino rabbit

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

other: Distilled water

Amount / concentration applied:

0.5 g of test item mixed with 0.5 ml of distilled water

Duration of treatment / exposure:

24 hours

Observation period:

72 hours

Number of animals:

not specified

Irritation parameter:

erythema score

Basis:

mean

Time point:

72 h

Remarks on result:

no indication of irritation

Irritation parameter:

edema score

Basis:

mean

Time point:

72 h

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

None of the animals showed any observable response to treatment throughout the 72 hours observation period.

Interpretation of results:

GHS criteria not met

Conclusions:

Sample 507-43 is not considered to be an irritant to rabbit skin.

Executive summary:

Sample 507-43 was tested according to the procedure prescribed by the Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.41, a transcript of which is attached as an Appendix to the full study report.

0.5 g of the sample 507-43 was mixed with 0.5 ml of distilled water before application to the skin of tested rabbits.

None of the animals showed any observable response to treatment throughout the 72 hours observation period. 

Therefore, sample 507-43 is not considered to be an irritant to rabbit skin.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: The Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.42

GLP compliance:

no

Specific details on test material used for the study:

Sample code n°: 507-43

Species:

rabbit

Strain:

other: Albino rabbit

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

79 mg

Observation period (in vivo):

14 days

Number of animals or in vitro replicates:

6 animals

Irritation parameter:

chemosis score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

1

Reversibility:

fully reversible within: 1 day

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

24/48/72 h

Score:

0.72

Max. score:

1

Reversibility:

fully reversible within: 7 days

Irritation parameter:

iris score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

0

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Max. score:

0

Irritant / corrosive response data:

The numerical scores awarded to the ocular reactions elicited by test sample 507-43 are given in section "Any other information on results incl. tables".
None of the animals gave a positive reaction. Mild conjunctival reactions (redness) were observed in all six animals.

The numerical scores awarded to the ocular reactions elicited by Sample 507-43 are presented in Table 1 below:  

 

Table 1

Animal No.	Region of eye	Day						Positive (+) or Negative (-) Result
		1	2	3	4	7	14
1	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	0	1	1	1	1	0
	Conjunctivae chemosis	0	0	0	0	0	0
2	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	1	1	1	1	1	0
	Conjunctivae chemosis	1	0	0	0	0	0
3	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	1	1	1	0	0	0
	Conjunctivae chemosis	0	0	0	0	0	0
4	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	1	1	1	0	0	0
	Conjunctivae chemosis	0	0	0	0	0	0
5	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	1	0	0	0	0	0
	Conjunctivae chemosis	0	0	0	0	0	0
6	Cornea	0	0	0	0	0	0	-
	Iris	0	0	0	0	0	0
	Conjunctivae redness	1	0	0	0	0	0
	Conjunctivae chemosis	0	0	0	0	0	0

 

Interpretation of results:

GHS criteria not met

Conclusions:

Sample 507-43 gave a negative result for eye irritation, according to the definition given in the Code of Federal Regulations of the U.S.A.

Executive summary:

The procedure employed was that prescribed by The Consumer Product Safety Commission of the U.S.A. in The Code of Federal Regulations, Title 16, Section 1500.42, a transcript of which is attached as an Appendix to the full study report.

For the test, 79 mg of sample 507-43 was instilled into one eye of each six animals, while the untreated eye was used as concurrent control. 

The numerical scores awarded to the ocular reactions elicited by 507-43 are given in Table 1: none of the animals gave a positive reaction and only mild conjunctival reactions were observed in all six animals.

Sample 507-43 gave a negative test for eye irritation, according to the definition given in the Code of Federal Regulations of the U.S.A.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Justification for classification or non-classification

Skin irritation:
None of the animals showed any observable response to treatment throughout the 72 hours observation period. Therefore, the test item is not considered to be an irritant to rabbit skin.

 

Eye irritation: 
None of the animals gave a positive reaction and only mild conjunctival reactions were observed in all six animals. The test item gave a negative test for eye irritation, according to the definition given in the Code of Federal Regulations of the U.S.A.