Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed database

Data source

Referenceopen allclose all

Reference Type:
other: secondary source
Title:
TOXNET
Author:
HSDB database
Year:
1991
Bibliographic source:
https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~DZCJh5:3
Reference Type:
review article or handbook
Title:
Documentation of the Threshold Limit Values and Biological Exposure Indices
Author:
American Conference of Governmental Industrial Hygienists, Inc.
Year:
1991
Bibliographic source:
American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 929

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
not specified in database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Propyne
EC Number:
200-828-4
EC Name:
Propyne
Cas Number:
74-99-7
Molecular formula:
C3H4
IUPAC Name:
prop-1-yne
Test material form:
gas

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation

Results and discussion

Effect levels
Key result
Remarks on result:
other: see remarks
Remarks:
no dose descriptor specified; see "Any other information on results"

Any other information on results incl. tables

Acute Exposure/ Rats that inhaled 42,000 ppm methyl acetylene became hyperactive and within 7 min were lethargic and ataxic. After 95 min, the animals were completely anesthetized. There was no mortality when the exposure was terminated at the end of 5 hr, and most of the animals recovered completely within 40 min. Edema and alveolar hemorrhage were present in animals killed at termination of the single exposure, whereas bronchiolitis and pneumonitis were observed in rats sacrificed 9 days postexposure.

Applicant's summary and conclusion

Executive summary:

There is no available information on the methods used to determine the value for this endpoint. However, this information is taken from the TOXNET website which is considered to be a reliable peer reviewed data source.

Acute Exposure: Rats that inhaled 42,000 ppm methyl acetylene became hyperactive and within 7 min were lethargic and ataxic. After 95 min, the animals were completely anesthetized. There was no mortality when the exposure was terminated at the end of 5 hr, and most of the animals recovered completely within 40 min. Edema and alveolar hemorrhage were present in animals killed at termination of the single exposure, whereas bronchiolitis and pneumonitis were observed in rats sacrificed 9 days postexposure.