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EC number: 248-688-3 | CAS number: 27841-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 - 15 Dec 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (purity not reported, no analytical monitoring)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Water Accommodated Fraction (WAF): This WAF was prepared by moderately stirring 100 mg test substance per liter of medium overnight
followed by filtration (MILLIPORE AP15 glass fiber filter).
- Controls: yes, water controls - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Length at study initiation: < 2mm
- Method of breeding: Parental and young Daphnia were held in 40L glass aquaria with a frequency of feeding once a day, except weekends, of 15 g sera micropan (homogenised in 1 L deionised water). The temperature was 20 ± 2 °C with an illumination of 16 h per day.
- Feeding during test: none
ACCLIMATION
- Acclimation period: 4 hours
- Acclimation conditions (same as test or not): same as test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20.0 ± 0.5 °C
- pH:
- control: 7.5 - 7.6
100 mg/L: 6.7 - 7.5 - Dissolved oxygen:
- control: 6.0 mg/L
100 mg/L: 5.8 - 6.0 mg/L - Nominal and measured concentrations:
- Nominal: 0 and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: all-glass, 100 mL flasks, with 50 mL of test medium
- Aeration: no
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water according to ISO 6341, prepared with distilled water.
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1
- Na/K ratio: 10:1
- Culture medium different from test medium: No, but test medium was not aerated as the culture medium.
- Intervals of water quality measurement: Temperature determined in a control flask at the start and at the end of the test. Oxygen and pH were
determined in all vessels prior to the addition of Daphnia to the test medium and at the end of the test.
OTHER TEST CONDITIONS
- Photoperiod: 16 h a day, supplied by overhead white fluorescent tubes.
EFFECT PARAMETERS MEASURED: Observations of immobile Daphnia were made after 24 and 48 h of exposure. - Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to analogue justification document provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- source, CAS 85186-86-3, Oleon, 2007, D. magna 48 h, RL2
- Duration:
- 48 h
- Dose descriptor:
- EL0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- source, CAS 85186-86-3, Oleon, 2007, D. magna 48 h, RL2
- Conclusions:
- No effects were observed up to the limit of water solubility.
Referenceopen allclose all
Table 1: Acute immobilisation of Daphnia magna after 24 and 48 hours of exposure
Nominal concentration (mg/l) |
Code |
Number of individuals per test vessel |
Immobile Daphnia (No./vessel) 24h |
Immobile Daphnia (No./vessel) 48h |
% immobile Daphnia after 24h of exposure |
% immobile Daphnia after 48h of exposure |
Control |
A B C |
20 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
100 |
A B |
20 |
0 0 |
0 0 |
0 0 |
0 0 |
Description of key information
EL50 (48h) > 100 mg/L (nominal; Daphnia magna); no effects up to the limit of water solubility; read-across
Key value for chemical safety assessment
Additional information
There is no study available in which the short-term toxicity of Neopentyl glycol dicaprate (CAS No. 27841-06-1) to aquatic invertebrates was assessed. Therefore, read-across to the structurally and chemically closely related source substance Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS 85186-86-3) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, section 1.5 in order to fulfill the data requirements for this substance. The source substance is characterized by similar chemical structure and is therefore considered a suitable representative for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. A detailed read-across justification in provided in IUCLID section 13.
The study conducted with the source substance Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS 85186-86-3) was conducted under static conditions and according to OECD Guideline 202, usingDaphnia magnaas test organism. A 100 mg/L loading rate, prepared as Water Accommodated Fraction (WAF), was applied in a limit test. No immobility was observed in the control and the treatment during the 48 h exposure period. Hence, the EL50 (48 h) was determined as > 100 mg/L loading rate (WAF, nominal). No effects up to the limit of water solubility are expected. Based on the available results from a structurally related read-across substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Neopentyl glycol dicaprate (CAS No. 27841-06-1) is not actuely toxic to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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