Registration Dossier
Registration Dossier
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EC number: 201-127-6 | CAS number: 78-62-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 0
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- A biodegradation rate of 0% was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Description of key information
Diethoxy(dimethyl)silane (CAS 78-62-6) is not readily biodegradable (0% after 28 d) based on read across from CAS 1066-40-6.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
There are no data on biodegradation for Diethoxy(dimethyl)silane (CAS 78-62-6). In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and in accordance with the Read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance trimethylsilanol (CAS 1066-40-6) has been applied to support the environmental hazard assessment of diethoxy(dimethyl)silane (CAS 78-62-6). Details on read across justifications can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13. The available study (2008) investigating the biodegradation of the analogue substance trimethylsilanol (CAS 1066-40-6) was conducted according to OECD 310, under GLP conditions. The inoculum (non-adapted activated sludge from a sewage treatment plant) was exposed for 28 days to the test substance and biodegradation was calculated based on inorganic C-analysis. No biodegradation of the substance was recorded after 28 d (0.0%). Thus, the substance is not readily biodegradable according to the OECD criteria. Based on the results of the analogue substance, Diethoxy(dimethyl)silane (CAS 78-62-6) is not assumed to be readily biodegradable.
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