Registration Dossier
Registration Dossier
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EC number: 232-311-4 | CAS number: 8002-50-4 Extractives and their physically modified derivatives such as proteins, carbohydrates, lipids, nucleic acids, inorganic ions, etc. obtained from Brevoortia tyrannis.
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the Class (esters) and the Baseline Toxicity (neutral organic structure analysis relationship).
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CCCCCCCCCCCCCCCC(=O)(OCC(COC(=O)(CCCCCCCC=CCC=CCCCCC))OC(=O)(CCCCCCCCCCCCCCCCCCC)); MOL FOR: C57 H106 O6; MOL WT : 887.48; Log Kow: 23.506 (EPISuite Kowwin v1.68 Estimate); Wat Sol: 1.619E-020 (mg/L, EPISuite WSKowwin v1.43 Estimate); Calculation is based on the structure and / or properties of oils, menhaden.
- Analytical monitoring:
- not required
- Test organisms (species):
- Daphnia sp.
- Test type:
- other: calculation
- Dose descriptor:
- other: ChV
- Effect conc.:
- 0 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- other: ChV: Chronic toxicity Value
- Details on results:
- Asterisk designates: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculated ChV to daphnia for oils, menhaden is 9.58e-015 mg/L.
- Executive summary:
The long-term toxicity to daphnia is calculated by ECOSAR v1.11. ChV value for daphnia is 9.58E-15 mg/L derived by calculation from ECOSAR class Esters. The calculated ChV Neutral Organic Structure Analysis Relationship (baseline toxicity) for daphnia is 3.58E-15 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=8.0), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Reference
Description of key information
The long-term toxicity to daphnia is calculated by ECOSAR v1.11. ChV value for daphnia is 9.58E-15 mg/L derived by calculation from ECOSAR class Esters. The calculated ChV Neutral Organic Structure Analysis Relationship (baseline toxicity) for daphnia is 3.58E-15 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=8.0), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Key value for chemical safety assessment
Additional information
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