4'-methoxyacetophenone

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975-07-18

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

according to an internal method

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4'-methoxyacetophenone

EC Number:

202-815-9

EC Name:

4'-methoxyacetophenone

Cas Number:

100-06-1

Molecular formula:

C9H10O2

IUPAC Name:

1-(4-methoxyphenyl)ethanone

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

not specified

Duration of exposure:

14 days

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10 animals (sex not specified)

Control animals:

no

Details on study design:

not available

Statistics:

not specified

Results and discussion

Preliminary study:

Not performed.

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

none (0/10 animals)

Clinical signs:

other: not recorded

Gross pathology:

Slight redness - 1/10 animals
Moderate redness - 9/10 animals
Slight edema - 3/10 animals
Moderate edema - 7/10 animals

Other findings:

none

Any other information on results incl. tables

Table: Results on mortality

Dose [g/kg]	Deaths/No. of animals	Observation Day
		1	2	3	4	5	6	7	8	9	10	11	12	13	14
5	0/10	0	0	0	0	0	0	0	0	0	0	0	0	0	0

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute dermal toxicity study with 5000 mg/kg bw of the test substance caused no mortality in rabbits and therefore a LD50 of > 5000 mg/kg bw was derived.

Executive summary:

In an acute toxicity study, 10 rabbits were dermally exposed once with the test substance at a single dose of 5000 mg/kg bw and were observed for a period of 14 days (similar to OECD 402). No mortallity was observed during the test. The LD50 value of the test material was established to be > 5000 mg/kg bw.