Hydroxyoctadecanoic acid, monoester with glycerol

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.1 mg/L

Assessment factor:

1 000

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

1 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.01 mg/L

Assessment factor:

10 000

Extrapolation method:

assessment factor

PNEC marine water (intermittent releases):

1 mg/L

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

1.5 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

19 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

1.9 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

2.2 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Conclusion on classification

In the absence of adequate aquatic chronic toxicity information from all three trophic levels, the classification was based on short-term aquatic toxicity values (72-h NOELR = 100 mg/L in algae, 48-h NOELR = 100 mg/L in daphnids, 96-h NOEC = 10,000 mg/L in fish). Based on the results of these three tests, no toxicity was observed in any of the three trophic levels; furthermore, there is no evidence that the acute toxicity tests do not provide a true measure of the intrinsic toxicity of the substance. Although the substance was not shown to be readily biodegradable, the substance exhibited inherent primary degradability and substantial mineralisation in the ready biodegradability assay (i.e., 49% degradation in 28 d); therefore, the substance is not expected to be persistent in the environment. The substance is composed of a glycerol ester of a fatty acid, and is expected to be rapidly metabolised in vertebrates. The bioconcentration factor (BCF = 44.1 L/kg w.w.) predicted by a validated QSAR model (EPI Suite BCFBAF v3.01) is below the criterion of concern for food chain exposures (BCF ≥ 100). Therefore, althoughthe substance has an estimated octanol-water partition coefficient (log K_ow) of 5.0779,which is above the criterion (log K_ow≥ 4.0) for possible environmental classification, food chain exposures and bioaccumulation of the substance are not of concern. In summary, there is no evidence that the acute toxicity tests do not provide a true measure of the intrinsic toxicity of the substance, which is not expected to be persistent or bioaccumulative in the environment. Therefore, the substance was not assigned a Category Chronic 4 classification, andwas not otherwise classified with respect to the aquatic environment.