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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 March 1999 - 27 April 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(2-aminoethyl)-N'-dodecylethylenediamine
EC Number:
223-035-5
EC Name:
N-(2-aminoethyl)-N'-dodecylethylenediamine
Cas Number:
3700-59-2
Molecular formula:
C16H37N3
IUPAC Name:
N-(2-aminoethyl)-N'-dodecylethane-1,2-diamine
Constituent 2
Chemical structure
Reference substance name:
N-(2-aminoethyl)-N'-tetradecylethylenediamine
Molecular formula:
C18H41N3
IUPAC Name:
N-(2-aminoethyl)-N'-tetradecylethylenediamine
Constituent 3
Chemical structure
Reference substance name:
N-(2-aminoethyl)-N-dodecylethylenediamine
EC Number:
224-056-2
EC Name:
N-(2-aminoethyl)-N-dodecylethylenediamine
Cas Number:
4182-44-9
Molecular formula:
C16H37N3
IUPAC Name:
N-(2-aminoethyl)-N-dodecylethane-1,2-diamine
Constituent 4
Chemical structure
Reference substance name:
N-(2-aminoethyl)-N-tetradecylethylenediamine
Molecular formula:
C18H41N3
IUPAC Name:
N-(2-aminoethyl)-N-tetradecylethylenediamine
Constituent 5
Reference substance name:
other constituents
IUPAC Name:
other constituents
Test material form:
liquid
Details on test material:
yelowish slightly turbid liquid
Density: ca. 0.86 g/ml
Expiry date: 10/99

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Doses:
2000 mg/kg bw; 200 mg/kg bw
No. of animals per sex per dose:
2000 mg/kg bw: 2 female animals 8preliminary study)
200 mg/kg bw: 2 femalee, 3 male rats
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - <= 2 000 mg/kg bw
Based on:
test mat.
Mortality:
2000 mg/kg bw: 2 animals
200 mg/kg bw: no mortality
Clinical signs:
other: no abnormal signs
Gross pathology:
no findings

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
An oral LD50 value of > 200 - < 2000 mg/kg bw was determined
Executive summary:

The acute oral toxicity of akyl chlorides, C12 -14, reaction products with diethylenetriamine was investigated in an OECD 423 study in Wistar rats. In a range finding study two female animals were found dead after 5.5 h after administration of a dose of 2000 mg/kg bw by gavage.

In the main study a dose of 200 mg/kg bw was administered by gavage to 3 females and 3 male animals. No mortalities, no abnormal clinical signs and no findings in gross pathology were detected in a 14 day post operation period.

An oral LD50 value between > 200 and <= 2000 mg/kg bw can therefore be concluded.